• Abeta from APP/PS1 Alzheimer mice hippocampus induced synaptic damage in vivo and in vitro 

      Sanchez-Varo, Raquel; De Castro, Vanessa; Trujillo-Estrada, Laura; Sanchez-Mejias, Elisabeth; Jimenez, Sebastian; [et al.] (2017-10-02)
      We aim to investigate the effects of Abeta from young APP/PS1 mouse model of Alzheimer`s disease (AD) on the synaptic integrity, as the loss of synapses strongly correlates with cognitive deficits in patients. Plaque-associated ...
    • Amyloid propagation in a sporadic model of Alzheimer disease 

      Andreo-Lopez, Juana; Cantero-Molina, Francisco; Bettinetti-Luque, Miriam; Huynh, Kelly; Nguyen, Marie; [et al.] (2021-11-04)
      Most age-associated neurodegenerative disorders involve the aggregation of specific proteins within the nervous system, as occurs in Alzheimer’s disease (AD). Recent evidence indicates that Aβ can misfold and aggregate ...
    • Amyloid-β seeding and propagation processes in a hAβ-KI model of Alzheimer's disease 

      Trujillo-Estrada, Laura; Minh Thu Nguyen, Marie; Baglietto-Vargas, David; LaFerla, Frank; Gutierrez-Perez, Antonia; [et al.] (Cold Spring Harbor Laboratory, 2020-12-02)
      Recent evidence indicates that Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prion-like process. Several studies using FAD animal models have demonstrated that ...
    • Impact of white adipose tissue in AD pathology 

      Bettinetti-Luque, Miriam; Andreo-Lopez, Juana; Cantero-Molina, Francisco; Trujillo-Estrada, Laura; Rodriguez-Ortiz, Carlos J; [et al.] (2021-11-04)
      Introduction: Alzheimer’s disease (AD) is a complex disorder and multiple cellular and molecular mechanisms are involved in AD onset and progression. Recent evidences has suggested that metabolic alterations are an important ...