• Amyloid-β seeding and propagation processes in a hAβ-KI model of Alzheimer's disease 

      Trujillo-Estrada, Laura; Minh Thu Nguyen, Marie; Baglietto-Vargas, David; LaFerla, Frank; Gutierrez-Perez, Antonia; [et al.] (Cold Spring Harbor Laboratory, 2020-12-02)
      Recent evidence indicates that Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prion-like process. Several studies using FAD animal models have demonstrated that ...
    • Microtubule stabilization reduces amyloid pathology and improves synaptic/memory deficits in APP/PS1 mice 

      Sanchez-Varo, Raquel; Fernandez Valenzuela, Juan José; Muñoz-Castro, Clara; De Castro, Vanessa; Sanchez-Mejias, Elisabet; [et al.] (Alzheimer disease & Parkinson disease Conference 2021, 2021)
      Aims: Cognitive decline in Alzheimer's disease (AD) is highly related to synaptic/neuronal loss. Tau hyperphosphorylation destabilizes microtubules leading to axonal transport failure and generation of dystrophic neurites, ...