• 18F-THK5351 PET imaging, neuropathology and clinical progression in a tau mouse model 

      Vegas-Gomez, Laura; Edwards III, George; Hasan, Omar; Gamez, Nazaret; Schulz, Jonathan; [et al.] (Alzheimer disease & Parkinson disease Conference 2021, 2021)
      Aims: Alzheimer’s disease (AD) and other associated dementias remain a consistent and unruly problem for the aging population and health. The neuropathology of AD is characterized by the extracellular deposition of ...
    • Analyzing hippocampal synaptic damage and glial response in a mouse model of tauopathy 

      Fernandez-Valenzuela, Juan José; Sánchez-Varo, Raquel; Navarro, Victoria; Jimenez, Sebastian; Sánchez-Mejias, Elisabeth; [et al.] (2017-10-04)
      Tau pathology is highly related to synaptic and neuronal loss, leading to cognitive decline and dementia in Alzheimer’s disease (AD) and other tauopathies. Tau transgenic mice are widely used to investigate the specific ...
    • Disentangling the contribution of tau and abeta pathologies in transgenic models of Alzheimer's disease 

      Sanchez-Varo, Raquel; Fernandez-Valenzuela, Juan José; Navarro, Victoria; Jimenez, Sebastian; Sanchez-Mejias, Elisabeth; [et al.] (2018-07-20)
      AIMS: Amyloid-beta (Abeta) deposits and intraneuronal hyperphosphorylated tau are major pathological hallmarks of Alzheimer’s disease (AD). The coexistence of these aggregates in AD brains leads to synaptic dysfunction, ...
    • Epothilone-d rescues cognition and attenuates alzheimer’s disease-like pathology in APP/PS1 mice 

      Ferbandez-Valenzuela, Juan Jose; Sanchez-Varo, Raquel; De Castro, Vanessa; Moyano, Francisco; Vizuete, Marisa; [et al.] (2016-09-09)
      AIMS: Cognitive decline in Alzheimer's disease (AD) patients has been linked to synaptic damage and neuronal loss. Hyperphosphorylation of tau protein destabilizes microtubules leading to the accumulation of autophagy/vesicular ...
    • Impact of white adipose tissue in AD pathology 

      Bettinetti-Luque, Miriam; Trujillo-Estrada, Laura; Andreo-Lopez, Juana; Cantero-Molina, Francisco; Rodriguez-Ortiz, Carlos J; [et al.] (2022)
      Aims: Alzheimer’s disease (AD) is a complex disorder and multiple cellular and molecular mechanisms are involved in AD onset and progression. Recent evidences has suggested that metabolic alterations are an important ...
    • Impact of white adipose tissue in AD pathology 

      Bettinetti-Luque, Miriam; Andreo-Lopez, Juana; Cantero-Molina, Francisco; Trujillo-Estrada, Laura; Rodriguez-Ortiz, Carlos J; [et al.] (2021-11-04)
      Introduction: Alzheimer’s disease (AD) is a complex disorder and multiple cellular and molecular mechanisms are involved in AD onset and progression. Recent evidences has suggested that metabolic alterations are an important ...
    • Longitudinal assessment of tau pet imaging and its correlation with neuropathology and clinical signs progression 

      Vegas-Gomez, Laura; Edwards, George A.; Hasan, Omar; Gamez, Nazaret; Schulz, Jonathan; [et al.] (Cold Spring Harbor Laboratory, 2020-12-02)
      Alzheimer’s disease (AD) and other associated dementias remain a consistent and unruly problem for the aging population and health. As the world’s population increases, so does the prevalence of age-related dementias. The ...
    • Tau pathology and astroglial reactivity: a comparative study of two mouse models of tauopathy 

      Fernandez-Valenzuela, Juan José; López Oliva, Elba; Sanchez-Varo, Raquel; Sanchez-Mejias, Elisabeth; Romero, Carmen; [et al.] (2022)
      Objectives: Astrocytes are becoming crucial players in the context of neurodegenerative proteinopathies, such as Alzheimer’s disease (AD). Astroglial response has been mainly analyzed in amyloidogenic scenarios, but less ...
    • WAT ALTERATIONS IN DIABETIC MICE: ITS CONNECTION AND IMPLICATION IN AD PATHOGENESIS 

      Bettinetti-Luque, Miriam; Trujillo-Estrada, Laura; Andreo-Lopez, Juana; Cantero-Molina, Francisco; Da Cunha, Celia; [et al.] (2022-07-13)
      Alzheimer’s disease (AD) is a complex disorder and multiple cellular and molecular mechanisms are involved in AD onset and progression. Recent evidences have suggested that metabolic alterations are an important pathological ...