Listar BCGF - Contribuciones a congresos científicos por título
Mostrando ítems 1-20 de 152
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18F-THK5351 PET imaging, neuropathology and clinical progression in a tau mouse model
(Alzheimer disease & Parkinson disease Conference 2021, 2021)Aims: Alzheimer’s disease (AD) and other associated dementias remain a consistent and unruly problem for the aging population and health. The neuropathology of AD is characterized by the extracellular deposition of ... -
A bacterial acetyltransferase targets the protein kinase ZIP1, a positive regulator of plant immunity
(2016-06-27)Pseudomonas syringae is a model bacterial pathogen that penetrates the leaf to reach the plant apoplast, where it replicates causing disease. In order to do that, the pathogen must interfere and suppress a two-tiered plant ... -
A model of maxilla resection to test new hybrid implants:macroporous titanium and tissue engineering elements
(2015-07-23)Maxillary bone loss in commonly found in humans, due to bone ageing, tooth loos, periodontal disease and, more severely, to trauma, radiotherapy and tumor resection. Masillofacial reconstructive surgery is a still unmet ... -
A model of neuroinflammation and demyelination by intracerebroventricular injection of microbial neuraminidase
(2014-07-14)Neuraminidase from Clostridium perfringens, which cleaves terminal sialic acid from carbohydrate chains, was injected in the lateral ventricle of rats. It diffused in the ipsilateral ventricle, the third ventricle, and ... -
A sensitive method to quantify replicative forms of circular DNA viruses
(2013-12-13)Although real-time PCR diagnostic protocols for detection of geminivirusesare available, none of them are able to discriminate between the two strands generated during an infection: the viral strand (VS) that is encapsidated ... -
A synthetic collagen-binding arg-gly-asp (rgd) biomimetic peptide enhances bone cell differentiation
(2013-11-27)RGD (arginine-glycine-aspartic acid) peptides have shown some promising abilities to promote the attachment of cells to biomaterials and to direct their differentiation. However, anchoring these peptides to the biomaterial’s ... -
Abeta from APP/PS1 Alzheimer mice hippocampus induced synaptic damage in vivo and in vitro
(2017-10-02)We aim to investigate the effects of Abeta from young APP/PS1 mouse model of Alzheimer`s disease (AD) on the synaptic integrity, as the loss of synapses strongly correlates with cognitive deficits in patients. Plaque-associated ... -
The absence of LPA1 receptor results in lipidome dysregulation and Neuropeptide-Y underexpression
(2018-07-18)LPA1 receptor is one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts as an intercellular signaling molecule. It has been shown that the LPA1 receptor is involved in ... -
Actividad antagonista de aislados del Virus de la Septicemia Hemorrágica Viral (VHSV) frente al sistema del interferón tipo I de lenguado senegalés
(2017-10-11)Senegalese sole (Solea senegalensis) is susceptible to marine Viral Haemorrhagic Septicaemia Virus (VHSV) isolates, but it is not affected by freshwater VHSV isolates. In addition, the sole type I interferon (IFN I) response ... -
Amyloid-b seeding and propagation processes in a hAb-KI model of Alzheimer's disease
(2020-12-17)Recent evidence indicates that Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prion-like process. Several studies using FAD animal models have demonstrated that ... -
Amyloid-β seeding and propagation processes in a hAβ-KI model of Alzheimer's disease
(Cold Spring Harbor Laboratory, 2020-12-02)Recent evidence indicates that Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prion-like process. Several studies using FAD animal models have demonstrated that ... -
Análisis bioinformático y funcional del sistema de secreción tipo III en cepas de Pseudomonas savastanoi aisladas de diversos huéspedes
(2017-05-30)La especie Pseudomonas savastanoi se engloba dentro del complejo Pseudomonas syringae, constituido por un conjunto de bacterias fitopatógenas Gram (-) de gran interés agrícola y económico. Dentro de esta especie, hay ... -
Análisis de la infección por geminivirus en plantas con la maquinaria de metilación del DNA alterada.
(2015-10-26)Los geminivirus son virus de plantas pertenecientes a la familia Geminiviridae. Poseen un genoma compuesto por una o dos moléculas de DNA circular de cadena simple y una cápside compuesta de 2 partes icosaédricas gemelas, ... -
Análisis del solapamiento funcional entre la respuesta de la planta frente a efectores secretados por Pseudomonas syringae y el silenciamiento génico
(2014-11-07)Las plantas están continuamente sometidas a infecciones por diferentes patógenos. Los patógenos bacterianos usan un complejo sistema de secreción para translocar proteínas efectoras al interior del huésped y suprimir así ... -
Análisis genómico y funcional de los efectores de las familias HopAF y HopAO del sistema de secreción tipo III de Pseudomonas savastanoi pv. savastanoi NCPPB 3335
(2015-03-17)Pseudomonas savastanoi pv. savastanoi (Psv) es el agente causal de la tuberculosis del olivo. El análisis bioinformático del borrador del genoma de Psv NCPPB 3335 permitió identificar 33 posibles efectores (T3E) del sistema ... -
Análisis genómico y transcriptómico de los efectores del sistema de secreción tipo III en Pseudomonas savastanoi pv. savastanoi NCPPB 3335
(2019)La especie Pseudomonas savastanoi pertenece al complejo Pseudomonas syringae, el cual está constituido por un conjunto de bacterias fitopatógenas Gram (-) de alto interés agrícola y económico. Dentro de esta especie se han ... -
Análisis metabolómico de la producción de compuestos indólicos por bacterias fitopatógenas del complejo Pseudomonas syringae
(2018-10-17)Las bacterias Gram negativas del complejo Pseudomonas syringae, entre las que se incluye Pseudomonas savastanoi, infectan gran variedad de plantas herbáceas y leñosas de relevancia agrícola y económica. Las cepas de P. ... -
Analysis of hypervariable DNA sequences by NGS technologies: QuasiFlow
(2016-11-14)The development of Next Generation Sequencing (NGS) technologies has allowed deep characterization of highly variable sequences such as viral or mitochondrial genomes. With respect to RNA and ssDNA viruses, their low ... -
Analysis of viral quasispecies by NGS technologies: quasiflow
(Sociedad Española de Virología, 2017)We have developed QuasiFlow, a workflow designed in AutoFlow that takes advantage of NGS technologies to reconstruct quasispecies based in Illumina reads. QuasiFlow characterises and computes several key parameters, such ... -
Analyzing hippocampal synaptic damage and glial response in a mouse model of tauopathy
(2017-10-04)Tau pathology is highly related to synaptic and neuronal loss, leading to cognitive decline and dementia in Alzheimer’s disease (AD) and other tauopathies. Tau transgenic mice are widely used to investigate the specific ...