• An ecological model of invasion and metastasis 

      Serrano, José J.; Urdiales-Ruiz, Jose Luis; Medina, Miguel Ángel; Montañez, Raúl (2017-08-29)
      It has been argued that malignat tumours represent complex dynamic and self-organizing ecosystems. Furthermore, there is increasing evidence that collective cell migration occurs during invasion and metastasis. Here, we ...
    • Evaluation of metabolism and biosignaling in the angiogenic microenvironment as potential targets for therapeutic intervention 

      Medina, Miguel Ángel; Ocaña-Ocaña, Maria del Carmen; Martínez-Poveda, Beatriz; Carrillo, Paloma; Urdiales-Ruiz, Jose Luis; [et al.] (2017-08-29)
      The "re-discovery" of Warburg effect at the turn of the present millennium has been a key determinant of the current renewed interest on cancer metabolism. In fact, metabolic reprogramming has been identified as one of the ...
    • Homocysteine treatment alters redox capacity of both endothelial and tumor cells 

      Díaz-Santiago, Elena; Rodríguez Caso, Luis; Cárdenas, Casimiro; Serrano, José J.; Quesada, Ana R.; [et al.] (2015-10-22)
      Homocysteine is a non-proteinogenic amino acid playing key roles in two interconnected metabolic pathways, namely, the activated methyl cycle and the linear trans-sulfuration pathway that allows the conversion of methionine ...