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- Biología Molecular y Bioquímica - (BMB)
- BMB - Contribuciones a congresos científicos
- Listar BMB - Contribuciones a congresos científicos por autor
Listar BMB - Contribuciones a congresos científicos por autor "Márquez-Gómez, Javier"
Mostrando ítems 1-5 de 5
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Changes in the nuclear proteomic profiling of human glioblastoma cells after glutaminase overexpression
Márquez-Gómez, Javier; Cardona Ramírez, Carolina; Alonso-Carrión, Francisco José; Lobo, Carolina; Campos-Sandoval, José Ángel; Martín Rufián, Mercedes[et al.] (2013)Human glutaminase (GA) enzymes are the products of two genes, GLS and GLS2. GA isozymes play markedly different roles in tumour biology: GLS isoforms (KGA and GAC) are related to cell growth and proliferation, whereas GLS2 ... -
Design and generation of a glutaminase GLS2 conditional knockout mice
Peñalver, Ana; Tosina, Marta; Martín-Rufián, Mercedes; Campos-Sandoval, José Ángel; Alonso-Carrión, Francisco José; Segura-Checa, Juan Antonio; Mates-Sánchez, José Manuel; Ramírez, Miguel Ángel; Gutiérrez-Adán, Alfonso; Márquez-Gómez, Javier[et al.] (2014-10-04)Mammalian glutaminase (GA; EC 3.5.1.2) is the main enzyme involved in brain generation of glutamate (Glu). This amino acid acts as an excitatory neurotransmitter within the CNS, and it is also implicated in behavioral ... -
Metabolic changes upon GLS inhibition by CB-839 in glioma cell lines
Santos Jiménez, Juan de los; Rosales, Tracy; Ko, Bookyung; Márquez-Gómez, Javier; Berardinis, Ralph J. de; Mates-Sánchez, José Manuel[et al.] (2012-07-19)Many tumors use Gln for both energy generation and as a biosynthetic precursor. Glutaminases (GAs) catalyze the first step of glutaminolysis by converting glutamine (Gln) into glutamate and ammonia in the mitochondria. In ... -
Metabolic impact of glutaminase isoenzymes modulation on glioma cell lines
De los Santos-Jiménez, Juan; Rosales, Tracy; Bookyung, Ko; Márquez-Gómez, Javier; DeBerardinis, Ralph J; Mates-Sánchez, José Manuel[et al.] (2022)Many tumors use glutamine for both energy generation and as a biosynthetic precursor. Glutaminases (GAs) catalyze the first step of glutaminolysis by converting glutamine (Gln) into glutamate and ammonia in the mitochondria. ... -
Ratones knock-out del receptor lpa1 de ácido lisofosfatídico presentan un acusado déficit de la isoenzima glutaminasa KGA (GLS) y una morfología alterada en las espinas dendríticas de hipocampo y corteza
Peñalver, Ana; Campos-Sandoval, José Ángel; Sánchez-Varo, Raquel María; Cardona Ramírez, Carolina; Castilla, Laura; Blanco, Eduardo; Martín-Rufián, Mercedes; Segura-Checa, Juan Antonio; Mates-Sánchez, José Manuel; Alonso-Carrión, Francisco José; Gutiérrez-Pérez, Antonia; Rodriguez-de-Fonseca, Fernando; Márquez-Gómez, Javier[et al.] (2015-09-25)Objectives: The objective of the present study was to utilize mice with knocked-down lysophosphatidic acid 1 (LPA1) receptor to ascertain changes in glutamatergic transmission that may help to explain part of the cognitive ...