• El análogo de las estrigolactonas GR-24 inhibe la angiogénesis in vitro e in vivo 

      Carrillo, Paloma; Martínez-Poveda, Beatriz; Medina, Miguel Ángel; Quesada, Ana R. (2016-10-03)
      Muchas fitohormonas han mostrado un gran potencial en la prevención y terapia contra el cáncer. Las estrigolactonas son hormonas vegetales derivadas de los caroteinoides que están implicadas en la inhibición de la ramificación ...
    • Antitumor and antiangiogenic potential of solomonamide synthesis intermediates 

      Carrilo, Paloma; Cheng-Sánchez, Iván; Ocaña, Mª Carmen; Martínez-Poveda, Beatriz; Medina, Miguel Ángel; [et al.] (2017-11-09)
      In this work we developed a new synthetic strategy towards the solomonamides. a novel class of cyclopeptides of marine origin. The described synthetic approach utilized an olefin metathesis reaction to form the [15]-membered ...
    • Estudios de preferencia metabólica en células del “microambiente angiogénico” 

      Ocaña, Mª Carmen; Martínez-Poveda, Beatriz; Quesada, Ana R.; Medina, Miguel Ángel (2016-10-03)
      El "redescubrimiento" del efecto Warburg a principios de este siglo XXI y de la elevada glutaminolisis tumoral han contribuido a un renovado interés por el metabolismo en Oncología. Además, estudios recientes han dado ...
    • Marine sponge as a source of antiangiogenic compounds. The case of aeroplysinin-1 

      Quesada, AR; Martínez-Poveda, B; Rodríguez-Nieto, S; Medina, Miguel Ángel (2014-04-02)
      The vast majority of the natural compounds that have been previously described as inhibitors of angiogenesis have been isolated from plants and terrestrial microorganisms, mainly due to their higher availability and because ...
    • Metabolic preference studies in cells of the tumor microenvironment 

      Ocaña, Mª Carmen; Martínez-Poveda, Beatriz; Quesada, Ana R.; Medina, Miguel Ángel (2016-10-03)
      In the last years, the rediscovery of the Warburg effect and high tumoral glutaminolysis has lead to a renewed interest in cancer metabolism. Moreover, recent studies have put some importance in endothelial cells metabolism. ...