• Cancer immunotherapy as a new treatment option 

      Burgos-Molina, Antonio Manuel; Padín-López, Alba; Alonso-Ortiz, Antonio (2019-01-16)
      Cancer can coaptate the immune control of the immune system (IS), evade immunity and its destruction. So, could we say openly that immunotherapy is a viable treatment option for patients with advanced cancer? Yes, ...
    • Case study of the intestinal microbiota using the XGN-MBI metagenomic assay 

      Burgos-Molina, Antonio Manuel; Mercado-Sáenz, Silvia; Gil-Carmona, Luisa; Morales-Moreno, Francisco; Ruiz-Gomez, Miguel Jose (2019-01-17)
      The microbiota of the colon and rectum is the most abundant and diverse of the human body, with a density of up to 1-2 kg of weight and a diversity that exceeds a thousand species. Metagenomics can be defined as the ...
    • Intestinal microbiota and colorectal cancer 

      Burgos-Molina, Antonio Manuel; Mercado-Sáenz, Silvia; Morales-Moreno, Francisco; Gil-Carmona, Luisa; Ruiz-Gómez, Miguel José (2019-01-16)
      Colorectal cancer may be influenced by changes in the intestinal microbiota that affect the mucosa and cause an immune response capable of producing inflammatory effects. Although there are still few studies in this regard, ...
    • Mechanisms of cross resistance between cisplatin and bleomycin in saccharomyces cerevisiae 

      Burgos-Molina, Antonio Manuel; Gil-Carmona, Luisa; Ruiz-Gómez, Miguel José (2019-01-16)
      Tumor cells can simultaneously acquire resistance against a diverse group of drugs. This phenomenon is called pleotropic resistance or multidrug resistance. This mechanism could explain the tumor resistance observed in ...
    • New markers of bleomycin resistance 

      Burgos-Molina, Antonio Manuel; Gil-Carmona, Luisa; Ruiz-Gómez, Miguel José (2019-01-16)
      Resistance to chemotherapy is one of the main problems of this type of therapy. Studies carried out determine the usefulness of predictive biomarkers to improve this treatment. The aim of this work is to carry out a ...
    • One hundred of cells generations connect the resistance to drugs and the replicative aging mechanisms 

      Burgos-Molina, Antonio Manuel; Gil-Carmona, Luisa; Ruiz-Gomez, Miguel Jose (2019-01-17)
      There are researchs that reveal a relationship between acquired resistance to antineoplastic drugs and aging. Therefore, the identification of genes involved in senescence could have a potential therapeutic utility for ...
    • Proteomic analysis in wild type and cisplatin resistant yeast strain of saccharomyces cerevisiae 

      Burgos-Molina, Antonio Manuel; Gil-Carmona, Luisa; Ruiz-Gómez, Miguel José (2019-01-16)
      Research carried out in oncology has allowed the identification and characterization of molecular markers of resistance to antineoplastic drugs. It supposes a great advance and allows the administration of customized ...
    • Real-time PCR optimization to identify Mycobacterium tuberculosis complex strains in clinical samples. 

      Sanjuan-Jimenez, Rocio; Colmenero, Juan de Dios; Morata, Pilar (2014-09-11)
      During recent years several molecular techniques have become available for Mycobacterium tuberculosis complex (MTC) detection,both for clinical samples and for isolates. One of the techniques more widely used is real time ...
    • Relationship between chronological aging and acquired resistance to cisplatin in the yeast saccharomyces cerevisiae 

      Burgos-Molina, Antonio Manuel; Mercado-Sáenz, Silvia; Gil-Carmona, Luisa; Ruiz-Gomez, Miguel Jose (2019-01-17)
      The Sir2 gene is associated with an increase in longevity in yeasts, worms, flies and rodents. The human homolog, Sirt1, is also involved in longevity, by inhibiting cellular senescence. Studies carry out in tumor cells ...
    • Resistance acquisition after seven cycles of in vitro bleomycin exposure 

      Burgos-Molina, Antonio Manuel; Gil-Carmona, Luisa; Lumbreras-Vega, Luis; Ruiz-Gómez, Miguel José (2019-01-16)
      Bleomycin is an antineoplastic drug that causes DNA damage by intra- and inter-strand crosslink and DNA strand breaks. This drug is used to treat several types of cancer. The aim of this work is to study the effect of ...
    • Resistance to bleomycin increases the chronological life of cells 

      Burgos-Molina, Antonio Manuel; Mercado-Sáenz, Silvia; Gil-Carmona, Luisa; Ruiz-Gomez, Miguel Jose (2019-01-17)
      The identification of genes involved in chronological aging could have a potential utility as molecular markers in the chemotherapy treatment of cancer. The aim of this work is to study the relationship between the ...
    • Selection of resistance to cisplatin in saccharomyces cerevisiae as a model for antineoplastic drugs studies 

      Burgos-Molina, Antonio Manuel; Lumbreras-Vega, Luis; Gil-Carmona, Luisa; Ruiz-Gómez, Miguel José (2019-01-16)
      The budding yeast (S. cerevisiae) is an excellent eukaryotic model to study the antineoplastic drugs effects, due to the well-characterized metabolic and genetic characteristics and the conserved similarity in molecular ...