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- Psicobiología y Metodología de las Ciencias del Comportamiento - (PMCC)
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Listar PMCC - Contribuciones a congresos científicos por autor "Santín-Núñez, Luis Javier"
Mostrando ítems 1-20 de 29
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Absence of LPA1 receptor results in altered pattern of limbic activation after tail suspension test
Moreno-Fernández, Román D.; Gómez-Salas, Francisco Javier; Pérez-Martín, Margarita; Rosell-del-Valle, Cristina; Castilla-Ortega, María Estela; García-Fernández, María Inmaculada; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo; Santín-Núñez, Luis Javier; Pedraza-Benítez, María del Carmen[et al.] (2016-07-20)Stress serves as an adaptive mechanism and helps organisms to cope with life-threatening situations. However, individual vulnerability to stress and dysregulation of this system may precipitate stress-related disorders ... -
Behavioral traits predicting cocaine-conditioned place reference in mice: role of anxiety adn the basolateral amygdala
Ladrón de Guevara-Miranda, David; Pavón-Morón, Francisco Javier; Serrano, Antonia; Rivera, Patricia; Estivill-Torrús, Guillermo; Suárez-Pérez, Juan; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (2016-07-13)Aims. The individual susceptibility to cocaine addiction, a factor of interest in the understanding and prevention of this disorder, may be predicted by certain behavioral traits. However, these are not usually taken into ... -
Chronic cocaine exposure during adolescence in mice induces alterations in hippocampal neurogenesis and spatial memory
Gil Rodríguez, Sara; Mañas-Padilla, María del Carmen; Berdugo-Gómez, Mario; Ávila-Gámiz, Fabiola; Romero Zerbo, Silvana Yanina; García-Fernández, María Inmaculada; Santín-Núñez, Luis Javier[et al.] (2022-07)Objectives: Cocaine is the second most widely consumed illicit drug even at early ages, with a prevalence of 2.9% in Spain in the 14-18 age group. Chronic consumption produces several cognitive-behavioral and hippocampal ... -
Cognitive impairment and persistent changes in exploration and hyperactivity in mice after withdrawn from chronic cocaine
Mañas-Padilla, María del Carmen; Ávila-Gámiz, Fabiola; Gil Rodríguez, Sara; Ladrón de Guevara-Miranda, David; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (2021)Lasting neurobehavioral adaptations such as cognitive decline are induced by chronic cocaine exposure in animal models. However, persistent changes in motor and exploratory responses are rarely reported. In this study, ... -
Cognitive impairment in a murine model of experimental autoimmune encephalomyelitis with relapsing-remitting course
Rosell-del-Valle, Cristina; Sánchez-Morales, Cristina; Gómez-Conde, Ana Isabel; Hurtado-Guerrero, Isaac; Fernández-Fernández, Óscar; Pedraza-Benítez, María del Carmen; Santín-Núñez, Luis Javier; Estivill-Torrús, Guillermo[et al.] (2015-09-18)Multiple sclerosis (MS) is a neuroinflammatory disorder characterized by demyelination and progressive axonal loss that affects the central nervous system. In addition of physical disability and the neurodegenerative ... -
Cognitive reserve mediates the severity of certain neuropsychological deficits related to cocaine use disorder
Sampedro-Piquero, Patricia; Vicario, Selene; Pérez-Rivas, Aroa; Ladrón de Guevara-Miranda, David; Santín-Núñez, Luis Javier (2020-03-17)Introduction: The concept of cognitive reserve (CR) is being considered in the field of substance use disorder (SUD) by observing that there are individuals whose brain alterations are not related to the cognitive ... -
Effect of a spatial memory training on the persistence of cocaine-contextual memory
Ávila-Gámiz, Fabiola; Mañas-Padilla, María del Carmen; Ladrón de Guevara-Miranda, David; Gil Rodríguez, Sara; Rodriguez-de-Fonseca, Fernando; Castilla-Ortega, María Estela; Santín-Núñez, Luis Javier[et al.] (2019-07-03)Modulation of hippocampal memories related with cocaine addiction such as cocaine-context associations could have important clinical implications. It has been shown that learning-related experiences are potent modulators ... -
Effects of palmitoylethanolamide in cocaine-induced behaviours
Santín-Núñez, Luis Javier; Zambrana-Infantes, Emma; Galeano, Pablo; Rosell-del-Valle, Cristina; Ladrón de Guevara-Miranda, David; Castilla-Ortega, María Estela; Rodriguez-de-Fonseca, Fernando; Blanco-Calvo, Eduardo[et al.] (2016-07-13)Aims. Cocaine addiction is a chronically relapsing disorder characterized by the compulsion to seek and take the drug. Previous investigations have demonstrated that several drugs of abuse, as cocaine, can alter the levels ... -
Effects of sequential exposure to physical exercise and cognitive training on hippocampal neurogenesis in mice
Ávila-Gámiz, Fabiola; Pérez-Cano, Ana María; Mullor-Vigo, Rosa; Pérez-Berlanga, José Manuel; Zambrana-Infantes, Emma; Santín-Núñez, Luis Javier; Ladrón de Guevara-Miranda, David[et al.] (2022-07-13)AIMS: Physical exercise and cognitive training hippocampal dependent tasks are known to enhance adult hippocampal neurogenesis (AHN). Here we aimed to evaluate the effect of either a moderate-intensity exercise protocol, ... -
Enhancement of adult hippocampal neurogenesis by spatial memory training and its effect on the maintenance of cocaine-contextual memory
Ávila-Gámiz, Fabiola; Mañas-Padilla, María del Carmen; Ladrón de Guevara-Miranda, David; Gil Rodríguez, Sara; Rodriguez-de-Fonseca, Fernando; Castilla-Ortega, María Estela; Santín-Núñez, Luis Javier[et al.] (2019-10-01)Aims:Modulation of hippocampal memories related with cocaine addiction such as cocaine-context associations could have important clinical implications. It has been asserted that learning-related experiences promote hippocampal ... -
Enhancing adult hippocampal neurogenesis with lysophosphatidic acid: a proposal for erasing cocaine contextual memory
Ladrón de Guevara-Miranda, David; Moreno-Fernández, Román D.; Gil Rodríguez, Sara; Rosell-del-Valle, Cristina; Estivill-Torrús, Guillermo; Serrano, Antonia; Pavón-Morón, Francisco Javier; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (2018-06-28)Stimulating adult hippocampal neurogenesis (AHN) has been uncovered as a promising approach in the manipulation of retrograde memories. This work aims to study whether increasing AHN with lysophosphatidic acid (LPA, an ... -
Influence of neurogenic improvement strategies on extinction and reinstatement of cocaine-induced conditioned place preference
Mullor-Vigo, Rosa; Ávila-Gámiz, Fabiola; Zambrana-Infantes, Emma; Mañas-Padilla, María del Carmen; Gil Rodríguez, Sara; Santín-Núñez, Luis Javier; Ladrón de Guevara-Miranda, David; Santín-Núñez, Luis Javier[et al.] (2022)AIMS: Modulation of adult hippocampal neurogenesis (AHN) has been shown to influence the maintenance of drug-context associations. We aimed to study whether the enhancement of AHN by using a water maze spatial learning ... -
LPA1/3 receptor antagonist KI16425 as a novel treatment for the neurobehavioural effects of the ethanol
Ladrón de Guevara-Miranda, David; Sánchez-Marín, Laura; Alén, Francisco; Moreno-Fernández, Román D.; García-Fernández, María Inmaculada; Gil Rodríguez, Sara; Gavito, Ana L.; García-Marchena, Nuria; Pedraza-Benítez, María del Carmen; Pavón-Morón, Francisco Javier; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Serrano, Antonia; Castilla-Ortega, María Estela[et al.] (2017-07-24)Aims. The lysophosphatidic acid (LPA) is an ubiquitous lysophospholipid that acts through G-protein coupled receptors (LPA1-6), and it is involved in the modulation of emotional and motivational behaviors. Recent literature ... -
More adult-born dentate gyrus neurons to weaken cocaine-related retrograde memories: an in vivo strategy employing exogenous lysophosphatidic acid
Ladrón de Guevara-Miranda, David; Moreno-Fernández, Román D.; Gil Rodríguez, Sara; Rosell-del-Valle, Cristina; Estivill-Torrús, Guillermo; Serrano, Antonia; Pavón-Morón, Francisco Javier; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (2019-10-28)The post-training enhancement of adult hippocampal neurogenesis (AHN) has been receiving growing interest as a potential method to manipulate retrograde memories. Recent hypothesis suggest that the addition of adult-born ... -
Neuroprotective effects of insulin-like growth factor II in a mouse model of Parkinson's disease
Ladrón de Guevara-Miranda, David; Martin-Montañez, Elisa; Valverde, Nadia; Lara, Estrella; Romero Zerbo, Silvana Yanina; Millón-Peñuela, Carmelo; Boraldi, Federica; Ávila-Gámiz, Fabiola; Pérez-Cano, Ana María; Garrido-Gil, Pablo; Labandeira-García, José Luis; Santín-Núñez, Luis Javier; Pavía-Molina, José; García-Fernández, María Inmaculada[et al.] (2022-07-20)Progressive degeneration of the nigrostriatal dopaminergic pathway is a core, currently irreversible pathological hallmark of Parkinson’s disease (PD) that leads to a variety of motor and non-motor symptoms. Here, we aimed ... -
Persistent drug-associated memories coexist with hippocampal-dependent cognitive decline and altered adult hippocampal neurogenesis in mice withdrawn from cocaine.
Mañas-Padilla, María del Carmen; Gil-Rodríguez, Sara; Sampedro-Piquero, Patricia; Ávila-Gámiz, Fabiola; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (2019-10-01)Aims: Using a new animal model (‘chronic’ cocaine-induced conditioned place preference –CPP- paradigm), this work studied whether the long-term maintenance of cocaine-associated memories was concomitant to cognitive ... -
Pharmacogenetic inhibition of the infralimbic cortex promotes reinstatement of cocaine-context memories in mice.
Pérez-Cano, Ana María; Ávila-Gámiz, Fabiola; Pérez Berlanga, José Manuel; Santín-Núñez, Luis Javier; Ladrón de Guevara-Miranda, David (2023)Relapse is one of the main problems concerning treatment of cocaine use disorder. It have been suggested that the infralimbic cortex (IL), a division of the medial prefrontal cortex, is involved in extinction and reinstatement ... -
The presence of a social stimulus reduces cocaine seeking in a place preference conditioning paradigm.
Sampedro-Piquero, Patricia; Ávila-Gámiz, Fabiola; Moreno-Fernández, Román D.; Santín-Núñez, Luis Javier (2019-09-26)BACKGROUND: One challenge in the treatment of substance use disorders is to re-engage the interest toward non-drug-related activities. Among these activities, social interaction has had a prominent role due to its positive ... -
Reduction of adult hippocampal neurogenesis modifies brain functional connectivity and enhances cocaine-seeking in mice
Castilla-Ortega, María Estela; Ladrón de Guevara-Miranda, David; Blanco-Calvo, Eduardo; Serrano, Antonia; Pedraz, María; Estivill-Torrús, Guillermo; Pavón-Morón, Francisco Javier; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier[et al.] (2015-09-16)Recently, adult hippocampal neurogenesis has been proposed as a putative neuroplastic mechanism involved in those behavioural processes. In this work, we studied the effect of the inhibition of adult hippocampal neurogenesis ... -
Role of the LPA1 receptor in mood and emotional regulation
Moreno-Fernández, Román D.; Pérez-Martín, Margarita; Rosell-del-Valle, Cristina; Castilla-Ortega, María Estela; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo; Santín-Núñez, Luis Javier; Pedraza-Benítez, María del Carmen[et al.] (2015-09-16)Depression is a debilitating psychiatric condition characterized by anhedonia and behavioural despair among others symptoms. Despite the high prevalence and devastating impact of depression, underlying neurobiological ...