• Absence of LPA1 receptor results in altered pattern of limbic activation after tail suspension test 

      Moreno-Fernández, Román D.; Gómez-Salas, Francisco Javier; Pérez-Martín, Margarita; Rosell-Valle, Cristina; Castilla-Ortega, Estela; [et al.] (2016-07-20)
      Stress serves as an adaptive mechanism and helps organisms to cope with life-threatening situations. However, individual vulnerability to stress and dysregulation of this system may precipitate stress-related disorders ...
    • Chronic cocaine exposure during adolescence in mice induces alterations in hippocampal neurogenesis and spatial memory 

      Gil Rodríguez, Sara; Mañas Padilla, María del Carmen; Berdugo-Gómez, Mario; Ávila-Gámiz, Fabiola; Romero-Zerbo, Silvana Y.; [et al.] (2022-07)
      Objectives: Cocaine is the second most widely consumed illicit drug even at early ages, with a prevalence of 2.9% in Spain in the 14-18 age group. Chronic consumption produces several cognitive-behavioral and hippocampal ...
    • LPA1/3 receptor antagonist KI16425 as a novel treatment for the neurobehavioural effects of the ethanol 

      Ladrón--e Guevara Miranda, David; Sánchez-Marín, Laura; Alén, Francisco; Moreno-Fernández, Román D.; García-Fernández, Maria Inmaculada; [et al.] (2017-07-24)
      Aims. The lysophosphatidic acid (LPA) is an ubiquitous lysophospholipid that acts through G-protein coupled receptors (LPA1-6), and it is involved in the modulation of emotional and motivational behaviors. Recent literature ...
    • Neuroprotective effects of insulin-like growth factor II in a mouse model of Parkinson's disease 

      Ladrón de Guevara-Miranda, David; Martin-Montañez, Elisa; Valverde, Nadia; Lara, Estrella; Romero-Zerbo, Silvana Y.; [et al.] (2022-07-20)
      Progressive degeneration of the nigrostriatal dopaminergic pathway is a core, currently irreversible pathological hallmark of Parkinson’s disease (PD) that leads to a variety of motor and non-motor symptoms. Here, we aimed ...
    • Social avoidance and altered stress axis in a mouse model of anxious depression 

      Nieto-Quero, Andrea; Gómez-Salas, Francisco Javier; Moreno-Fernández, Román; Rosell-del-Valle, Cristina; Pérez-Martín, Margarita; [et al.] (2018-07-17)
      Prevalence of stress-related disorders, such as depression, is raising in modern societies. Indeed, current neurobiological research aims to elucidate the link between deregulation of the hypothalamic-pituitary-adrenal ...
    • Stress, depression and the hippocampus: modulatory effects of continuous LPA treatment 

      Moreno-Fernández, Román; Bacq, Alexandre; Rosell-Valle, Crisitina; Zanoletti, Olivia; Cifuentes, Manuel; [et al.] (2019-06-25)
      The LPA1, one of the six characterized G protein-coupled receptors (LPA1–6) through which lysophosphatidic acid acts may be involved in promoting normal emotional behaviors. Evidence also imply a role for the LPA1 receptor ...
    • The limbic brain under stress: a role for the LPA1 receptor 

      Moreno-Fernández, Román D.; Tabbai, S.; Gómez-Salas, Francisco Javier; Pérez-Martín, Margarita; Rosell-Valle, Cristina; [et al.] (UNED, 2017-07)
      Adverse events can impact brain structure and function and are considered primary sources of risk for depression, anxiety, and other psychiatric disorders. In this sense, the neurobiological circuitry in charge of dealing ...
    • Treadmill exercise buffers behavioral alterations related to ethanol binge-drinking in adolescent mice. 

      Sampedro-Piquero, Patricia; Millón, Carmelo; Moreno-Fernández, Román; García-Fernández, Maria Inmaculada; Díaz-Cabiale, Zaida; [et al.] (2020-07-24)
      The binge-drinking pattern of EtOH consumption, which is frequently observed in adolescents, is known to induce several neurobehavioral alterations, but protection strategies against these impairments remain scarcely ...
    • What role does the LPA1 receptor play in regulating emotional-like behaviours? 

      Pedraza-Sánchez-López, J.; Castilla-Ortega, Estela; Rosell-Valle, Cristina; Moreno-Fernández, Román D.; Zambrana-Infantes, Emma; [et al.] (2015-07-24)
      The LPA1 receptor is one of the six characterized G protein-coupled receptors (LPA1–6) through which lysophosphatidic acid acts as an intercellular signalling molecule. It has been proposed that this receptor has a role ...