Listar Química Orgánica - (QO) por título
Mostrando ítems 21-40 de 121
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Design of multi-haptenized dendrimeric-antigens for in vitro IgE recognition
(2014-06-12)Reactions mediated by the Immunoglobulin E (IgE) involved a high number of allergic drug responses, ranging from simple skin symptoms to anaphylactic shock.1 In order to emulate the recognition process working in vivo, ... -
Detecting hydroxyl radical with a new two-photon fluorescent probe in living cells
(Real Sociedad Española de Química, 2018-06-20)Reactive oxygen species (ROS) are known to be involved in the onset and development of multiple diseases, including cancer, cardiovascular diseases, neurodegenerative diseases and diabetes among others. Generation of ROS ... -
Development of Novel Nanobiosensors for Diagnostics of Adverse Drug Reactions.
(UMA Editorial, 2023)Amoxicilina es uno de los antibioticos del grupo de penicilinas más usados. Penicilinas son el grupo de antibioticos que provocan más reaciones alérgicas entre todos los medicamentos. Diagnóstico correcto es necesario para ... -
Diastereoselective C-alkylation of aldimines, derived from chiral alpha-carbon heteroatom substituted aldehydes, with triethylborane. Application to the synthesis of benzylisoquinolines
(Royal Society of Chemistry, 2023-03-13)The one-pot reaction of a chiral aldehyde, p-methoxyaniline or p-fluoroaniline, and triethylborane produces the corresponding alkylated chiral amine with high yields and distereoisomeric ratios. Stereocontrol is induced ... -
Diastereoselective synthesis of chiral amines by imines alkylation
(2013-10-03)En esta comunicación se aborda la síntesis de aminas quirales utilizando como agente alquilante trietilborano. -
Direct characterization of functional materials by haptenized fluorescent dendrimers for in vitro allergic drug diagnose
(2020-10-01)β-lactams are the most widely drug prescribed against infections, but they are the most commonly reported medication allergy too. A correct diagnosis of these allergic reactions is crucial to avoid rejecting them by other ... -
Diseño de dendrímeros amino-terminales basados en enlaces tipo amidas. Estructuras con menor repulsión estérica y síntesis a gran escala
(2022-05-30)La estructura ramificada y la elevada multivalencia que presentan los dendrímeros los convierten en excelentes compuestos con potenciales aplicaciones en el campo de la biomedicina. En concreto, los dendrímeros con grupos ... -
Diseño y aplicaciones de compuestos fotoactivos
(2014-03-20)Además del interés de la fotoquímica a nivel molecular, recientemente se han desarrollado nuevas y más complejas aplicaciones para explotar la energía lumínica: fotocatálisis, sensores y lanzamiento de señales, máquinas ... -
Diseño y síntesis de nuevos dendrímeros
(2018-03-06)Los dendrímeros son excelentes plataformas multifuncionales para una gran cantidad de diferentes aplicaciones. En particular, el desarrollo de nanoestructuras moleculares multivalentes, con tamaño y forma bien definida, ... -
Diseño y síntesis de nuevos dendrímeros y dendrones. Aplicaciones en regeneración tisular
(2018-03-06)Los dendrímeros han generado un enorme interés debido a su particular estructura ramificada y su multivalencia. La extensa investigación que se ha llevado a cabo sobre este tipo de macromoléculas ha demostrado la naturaleza ... -
Diseño y síntesis de nuevos dendrones para aplicaciones biomédicas
(2018-03-06)Los dendrímeros han sido empleados en una gran variedad de aplicaciones, entre las que destacan las del campo de la biomedicina. Estas macromoléculas multivalentes ofrecen la posibilidad de incorporar múltiples funcionalidades ... -
El proceso de descubrimiento de fármacos en Janssen: Diseño de mGlu2Nams
(2018-10-23)Susana Conde es actualmente “Principal Scientist” y Team Leader del departamento de Química Médica de Janssen en España. Su trayectoria investigadora ha sido brillante, siendo doctora en Química Orgánica por la Universidad ... -
Electrospun nanofibers: recent applications in drug delivery and cancer therapy
(MDPI, 2019-04)Polymeric nanofibers (NFs) have been extensively reported as a biocompatible scaffold to be specifically applied in several researching fields, including biomedical applications. The principal researching lines cover the ... -
Energy transfer in Aminonaphthalimide-BODIPY dyads upon one and two photons excitation
(2014-07-03)BODIPY dyes are nowadays widely commercialized chromophores that have attracted immense interest as versatile tools in biological chemistry [1]. However, the generally very small Stokes shifts of BODIPY dyes may cause ... -
Evaluation of anticancer and anti-inflammatory activities of some synthetic rearranged abietanes
(MDPI, 2023-09-01)Synthesis of the rearranged abietane diterpenes pygmaeocins C and D, viridoquinone, saprorthoquinone, and 1-deoxyviroxocine has been successfully achieved. The anticancer and anti-inflammatory activities of selected ... -
Fijación de dendrímeros antigénicos en superficies para determinación de IgE
(2016-02-15)Actualmente, el diseño de nuevos materiales con potenciales aplicaciones biomédicas es de gran importancia , sobre todo para su uso directo en diagnóstico clínico . En particular, los dispositivos que ... -
Fine-Tuning of biological interactions towards directed cell response
(2014-03-20)Cells can sense and respond to their local environment. Therefore, engineering the material properties so that it can interface with cells and elucidate specific biological responses is key step in biomaterials design. ... -
Glycomimetic Ligands for C-type Lectin Recognition.
(2023)C-type lectin receptors (CLRs) represent pivotal sensory mechanisms orchestrating the primary immune response via dendritic cells.1 The exploration of non-native ligands as molecular tools for the manipulation of CLRs has ... -
Green synthesis of silver nanoparticles and its combination with Pyropia columbina (Rhodophyta) extracts for a cosmeceutical application
(MDPI, 2023-03-10)We report the green synthesis of silver nanoparticles (AgNPs) by using daisy petals (Bellis perennis), leek (Allium porrum) and garlic skin (Allium sativum) as reducing agents and water as solvent. AgNPs are obtained with ... -
Hybrid pH-Responsive Au@p4VP Microgels as Platform for Selective SERS Analysis
(2017-09-21)We present the synthesis a of pH-responsive core@shell hybrid microgel. This colloidal system is formed by a 55 nm Au core individually covered by a polymeric pH-sensitive shell of poly(4-vinylpyridine), that we denote as ...