Química Orgánica - (QO): Envíos recientes
Mostrando ítems 1-20 de 121
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Participación de los eicosanoides en la hipersensibilidad cruzada a anti-inflamatorios no esteroideos: mecanismos y base genética.
(UMA Editorial, 2024)Las reacciones de hipersensibilidad cruzada a anti-inflamatorios no esteroideos (RHC-AINEs) son la primera causa de hipersensibilidad a fármacos, siendo la urticaria/angioedema agudos (NIUA) la entidad clínica más frecuente. ... -
Nanoscale biocompatible structures generated from fluorinated tripodal phenylenes on gold nanoprisms
(Wiley, 2022-03-09)Modification of gold substrates with a stable, uniform and ultrathin layer of biocompatible materials is of tremendous interest for the development of bio-devices. We present the fabrication of hybrid systems consisting ... -
Electrospun nanofibers: recent applications in drug delivery and cancer therapy
(MDPI, 2019-04)Polymeric nanofibers (NFs) have been extensively reported as a biocompatible scaffold to be specifically applied in several researching fields, including biomedical applications. The principal researching lines cover the ... -
Magnetically active pNIPAM nanosystems as temperature-sensitive biocompatible structures for controlled drug delivery
(Taylor and Francis, 2020-04-19)Here, temperature-sensitive hybrid poly(N-isopropylacrylamide) (pNIPAM) nanosystems with magnetic response are synthesised and investigated for controlled release of 5-fluorouracil (5FU) and oxaliplatin (OXA). Initially, ... -
n-Tuples on Scaffold Diversity Inspired by Drug Hybridisation to Enhance Drugability: Application to Cytarabine
(MDPI, 2023-12-13)A mathematical concept, n-tuples are originally applied to medicinal chemistry, especially with the creation of scaffold diversity inspired by the hybridisation of different commercial drugs with cytarabine, a synthetic ... -
Diastereoselective C-alkylation of aldimines, derived from chiral alpha-carbon heteroatom substituted aldehydes, with triethylborane. Application to the synthesis of benzylisoquinolines
(Royal Society of Chemistry, 2023-03-13)The one-pot reaction of a chiral aldehyde, p-methoxyaniline or p-fluoroaniline, and triethylborane produces the corresponding alkylated chiral amine with high yields and distereoisomeric ratios. Stereocontrol is induced ... -
Tripod-shaped molecules: Synthesis and immobilization on Au(1 1 1) substrates.
(2018-11-09)We describe design and synthesis of novel tripod-shaped molecules that are potentially capable of monomolecular assembly on noble metal substrates, maintaining, due to their rigidity and specific geometry, the orientation ... -
SPION Nanoparticles for Delivery of Dopaminergic Isoquinoline and Benzazepine Derivatives.
(Elsevier, 2022-06-27)Superparamagnetic iron nanoparticles (SPIONs) have become one of the most useful colloidal systems in nanomedicine. We report here the preparation of new hybrid core@shell systems based on SPION nanoparticles coated with ... -
Tripodal penta(p-phenylene) for the biofunctionalization of alkynyl-modified silicon surfaces.
(Elsevier, 2018-03-22)Here we report the optimization on the covalent grafting methodology of a tripod-shaped penta(p-phenylene), 1, on alkynyl-terminated silicon surfaces, and the incorporation of an active theophylline derivative, 2, for the ... -
Synthesis and dopaminergic activity of a series of new 1-aryl tetrahydroisoquinolines and 2-substituted 1-aryl-3-tetrahydrobenzazepines.
(Elsevier, 2018-07-05)A series of new 1-aryl-6,7-dihydroxy tetrahydroisoquinolines with several substitution patterns in the 1-aryl group at C-1 were prepared in good yields. The influence of each substituent on the affinity and selectivity for ... -
Evaluation of anticancer and anti-inflammatory activities of some synthetic rearranged abietanes
(MDPI, 2023-09-01)Synthesis of the rearranged abietane diterpenes pygmaeocins C and D, viridoquinone, saprorthoquinone, and 1-deoxyviroxocine has been successfully achieved. The anticancer and anti-inflammatory activities of selected ... -
Silica Particle based nanocomposites for Specific IgE Determination to Betalactams
(2023)Current immunoassays for diagnosing betalactam (BL) allergy have limited sensitivity and poor specificity. These include ImmunoCAP, the commercial immunoassay, and the radioallergosorbent test (RAST), a handmade test ... -
Smart design of iron oxide nanoparticles as a platform for tumor targeting and in vivo imaging
(UMA Editorial, 2023)Durante los últimos años se ha hecho un esfuerzo considerable en el desarrollo de nuevas aproximaciones terapéuticas y diagnósticas basadas en la nanotecnología para avanzar en el manejo del cáncer. Sin embargo, los ... -
Glycomimetic Ligands for C-type Lectin Recognition.
(2023)C-type lectin receptors (CLRs) represent pivotal sensory mechanisms orchestrating the primary immune response via dendritic cells.1 The exploration of non-native ligands as molecular tools for the manipulation of CLRs has ... -
Transition metal-free [2,3]-sigmatropic rearrangement in the reaction of sulfur ylides with allenoates
(RSC, 2023-08)An unprecedented transition metal free [2,3]-sigmatropic rearrangement involving stabilized sulfur ylides and allenoates has been thoroughly established. The scope and utility of this reaction have been extensively studied ... -
NanoFN10: A High-Contrast Turn-On Fluorescence Nanoprobe for Multiphoton Singlet Oxygen Imaging.
(MDPI, 2023-05-09)An “off-on” fluorescent nanoprobe for near-infrared multiphoton imaging of singlet oxygen has been developed. The nanoprobe comprises a naphthoxazole fluorescent unit and a singlet-oxygen-sensitive furan derivative attached ... -
Isolation of Mycosporine-like Amino Acids from Red Macroalgae and a Marine Lichen by High-Performance Countercurrent Chromatography: A Strategy to Obtain Biological UV-Filters.
(MDPI, 2023-06-10)Marine organisms have gained considerable biotechnological interest in recent years due to their wide variety of bioactive compounds with potential applications. Mycosporine-like amino acids (MAAs) are UV-absorbing secondary ... -
Development of Novel Nanobiosensors for Diagnostics of Adverse Drug Reactions.
(UMA Editorial, 2023)Amoxicilina es uno de los antibioticos del grupo de penicilinas más usados. Penicilinas son el grupo de antibioticos que provocan más reaciones alérgicas entre todos los medicamentos. Diagnóstico correcto es necesario para ... -
Green synthesis of silver nanoparticles and its combination with Pyropia columbina (Rhodophyta) extracts for a cosmeceutical application
(MDPI, 2023-03-10)We report the green synthesis of silver nanoparticles (AgNPs) by using daisy petals (Bellis perennis), leek (Allium porrum) and garlic skin (Allium sativum) as reducing agents and water as solvent. AgNPs are obtained with ... -
Síntesis eficiente de estructuras dendriméricas amino terminales para aplicaciones biomédicas
(UMA Editorial, 2023)Un dendrímero se describe generalmente como una macromolécula que se caracteriza por poseer una estructura tridimensional altamente ramificada, ordenada y controlada, lo que le proporciona un alto grado de funcionalidad ...