Envíos recientes

  • Syntehsis and use of dendrimeric structures as a tool in biomedicine 

    Perez-Inestrosa, Ezequiel; Vida-Pol, Yolanda; Molina, Noemi; Morgado, Anjara; Najera-Albendin, Francisco (2019-10-28)
    Specific cell interactions of surfaces grafted dendrimers have been applied to the study of cell adhesion. We have studied also the application of dendrimer-based uneven nanopatterns to evaluate the local RGD surface density ...
  • “Off-on” two-photon indolenine probes for pH bioimaging 

    Benítez-Martín, Carlos; Guadix, Juan A.; Pearson, John R.; Najera-Albendin, Francisco; Perez-Pomares, Jose Maria; [et al.] (2019-10-25)
    Fluorescence-based biosensors have become an indispensable tool in modern biology. These molecules can be used to monitor processes inside living cells and in real-time. The control of the pH is crucial in multiple biological ...
  • RGD-dendritic structures on titanium alloy. Influence in the relationship between bone cells and the metal surface 

    Molina, Noemí; Gonzalez-Luque, Ana M.; Becerra-Ratia, Jose; Santos-Ruiz, Leonor; Vida-Pol, Yolanda; [et al.] (2019-09-18)
    Prosthetic implants are used in surgical procedures to replace a joint (hip or knee) allowing the functional recovery of the patient. Prostheses are usually made of titanium alloys. However, the lack of chemical and ...
  • Synthesis and Biological Evaluation of Depudecin Analogues 

    Cheng-Sánchez, Iván; Carrillo, Paloma; García-Ruiz, Cristina; Martínez-Poveda, Beatriz; Quesada, Ana R.; [et al.] (2019-09-18)
    (-)-Depudecin (1) (Figure 1), isolated from the culture broths of the fungus Alternaria brassicicola,1 and later, from the weed pathogen Nimbya scirpicola,2 has been identified as a selective inhibitor of histone deacetylases ...
  • Synthesis of new bengamide analogues and encapsulation into thermo-responsive magnetic nanoparticles 

    Porras Alcalá, Cristina (2019-09-16)
    The development and identification of new antitumoral drugs has become a research area of great interest and maximum priority. Firstly, to overcome the secondary effects frequently shown by current antitumorals and, secondly, ...
  • New Approaches in the Manufacture of Biomaterials for Betalactam Allergic Diagnose 

    Collado, Daniel; Perez-Inestrosa, Ezequiel; Ruiz-Sanchez, Antonio Jesus; Mayorga, Cristobalina; Torres-Jaen, Maria Josefa (2019-09-11)
    Betalactams are the most widely utilized drugs against infections but are the primary cause of allergic reactions to antibiotic drugs. REF1 An accurate diagnosis of these allergic reactions to betalactams is crucial to ...
  • Pt(II)-dendrimers as bio-imaging marker for bacteria in two-photon excitation microscopy 

    Vida-Pol, Yolanda; Molina, Noemi; Cnudde, Marvin; Guadix, Juan A.; Perez-Pomares, Jose M.; [et al.] (2019-07-25)
    The use of luminescent markers based on metal complexes in two-photon excitation microscopy techniques are of great interest in the field of bioimaging. However, despite the excellent luminescent properties of Pt(II) ...
  • Synthesis of New Analogues of the Bengamides to encapsulate in magnetic nanoparticles 

    ORTEGA RODRIGUEZ, ALICIA; PORRAS ALCALA, CRISTINA; CONTRERAS CACERES, RAFAEL; López-Romero, Juan Manuel; MELGUIZO, CONSOLACION; [et al.] (2019-05-15)
    The development and identification of new antitumoral has become a research area of great interest and maximum priority due to secondary effects of current antitumoral and the appearance of tumours resistant to these agents. ...
  • Thermorresponsive magnetic nanoparticles as target drug delivery for cancer treatment 

    ORTEGA RODRIGUEZ, ALICIA; PORRAS ALCALA, CRISTINA; CONTRERAS CACERES, RAFAEL; López-Romero, Juan Manuel; MELGUIZO, CONSOLACION; [et al.] (2019-05-15)
    In this research, temperature sensitive microgels with magnetic core for controlled release of 5-fluoruracil was synthesized. Magnetic nanoparticles (Fe3O4) were prepared by coprecipitation method and the surface was ...
  • Design and synthesis of new molecules based on indolium derivatives for two-photon absorption bioimaging applications 

    Benítez-Martín, Carlos; Nájera, Francisco; Pérez-Inestrosa, Ezequiel (2018-11-15)
    Bioimaging is the visualization of biological processes in real time, interfering as less as possible with these and using non-invasive methods. Among others, fluorescence methods have acquired a very important role in ...
  • Synthesis and biological activity of a new class of antitumor cyclopeptides based on the solomonamides 

    Cheng-Sánchez, Iván; Carrillo, Paloma; Martínez-Poveda, Beatriz; Quesada, Ana R.; Medina, MIguel A.; [et al.] (2018-10-15)
    Solomonamides A (1) and B (2) are novel natural products recently isolated from the marine sponge Theonella swinhoei [1]. Preliminary structural studies revealed an unprecedented cyclic peptide type structure. Interestingly, ...
  • Aminonaphtamiline-squaraine dyad: photophysical properties and bioimaging application 

    Collado, Daniel (2018-09-19)
    Squaraines is an important part of the cyanine family which have high extinction coefficients, sharp absorption bands, and intense fluorescence spectra in the red and near infrared region in solution.[1] The unique electronic ...
  • Tuning pKa in new molecules based on indolines for two-photon absorption bioimaging applications 

    Benitez-Martin, Carlos; Najera-Albendin, Francisco; Perez-de-Inestrosa-Villatoro, Ezequiel (Real Sociedad Española de Química, 2018-06-20)
    Fluorescence-based biosensors have become essential tools for modern biology, allowing real-time monitoring of biological processes within living cells. The differences between pH play a significant role in multiple ...
  • Detecting hydroxyl radical with a new two-photon fluorescent probe in living cells 

    Najera-Albendin, Francisco; Benitez-Martin, Carlos; Guadix, Juan Antonio; Perez-Pomares, Jose Maria; Perez-de-Inestrosa-Villatoro, Ezequiel (Real Sociedad Española de Química, 2018-06-20)
    Reactive oxygen species (ROS) are known to be involved in the onset and development of multiple diseases, including cancer, cardiovascular diseases, neurodegenerative diseases and diabetes among others. Generation of ROS ...
  • Diseño y síntesis de nuevos dendrímeros y dendrones. Aplicaciones en regeneración tisular 

    Vida-Pol, Yolanda; Molina, Noemi; Morgado, Anjara; Collado, Daniel; Najera-Albendin, Francisco; [et al.] (2018-03-06)
    Los dendrímeros han generado un enorme interés debido a su particular estructura ramificada y su multivalencia. La extensa investigación que se ha llevado a cabo sobre este tipo de macromoléculas ha demostrado la naturaleza ...
  • Diseño y síntesis de nuevos dendrímeros 

    Morgado, Anjara; Molina, Noemi; Collado, Daniel; Najera-Albendin, Francisco; Vida-Pol, Yolanda; [et al.] (2018-03-06)
    Los dendrímeros son excelentes plataformas multifuncionales para una gran cantidad de diferentes aplicaciones. En particular, el desarrollo de nanoestructuras moleculares multivalentes, con tamaño y forma bien definida, ...
  • Diseño y síntesis de nuevos dendrones para aplicaciones biomédicas 

    Molina, Noemi; Morgado, Anjara; Collado, Daniel; Najera-Albendin, Francisco; Vida-Pol, Yolanda; [et al.] (2018-03-06)
    Los dendrímeros han sido empleados en una gran variedad de aplicaciones, entre las que destacan las del campo de la biomedicina. Estas macromoléculas multivalentes ofrecen la posibilidad de incorporar múltiples funcionalidades ...
  • New molecules based indolium for two-photon absortion bioimaging applications 

    Benitez-Martin, Carlos; Pérez-Inestrosa, Ezequiel; Nájera, Francisco (Universidad de Extremadura, 2017)
    The development of organic materials with 2PA has attracted intensive attention in the past two decades. In two-photon bio-imaging applications the design of the chromophore requires to have a good cross-section and good ...
  • Hybrid pH-Responsive Au@p4VP Microgels as Platform for Selective SERS Analysis 

    Contreras Cáceres, Rafael (2017-09-21)
    We present the synthesis a of pH-responsive core@shell hybrid microgel. This colloidal system is formed by a 55 nm Au core individually covered by a polymeric pH-sensitive shell of poly(4-vinylpyridine), that we denote as ...
  • Synthesis and study of biological activity of tetrahydro-1H-[3]-benzazepines 

    Lucena-Serrano, Ana; Lucena Serrano, Cristina; López-Romero, Juan Manuel; Díaz, Amelia; Valpuesta-Fernandez, Maria (2017-07-20)
    The 3-Benzazepines are an important class of compounds in drug discovery due to their biological activity such as analgesic, antihypertensive or anticancer properties as well as dopaminergic or antidopaminergic activity. ...

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