QO - Contribuciones a congresos científicos
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Novel probes for simultaneous dual-colour labelling of mitochondria and lysosomes.
Cellular activity depends on the accurately controlled and synchronised functions of the subcellular organelle ensemble. In this context, lysosomes and mitochondria are central to cellular metabolism as major contributors ... -
Silica Particle based nanocomposites for Specific IgE Determination to Betalactams
Matamoros Castellano, Esther; Gil-Ocaña, Violeta; Jiménez, Isabel M.; Mayorga Mayorga, Cristobalina; Doña, Inmaculada; Céspedes Lagos, José Antonio; Montañez-Vega, María Isabel
; Vida-Pol, Yolanda; Pérez-de-Inestrosa-Villatoro, Ezequiel; Torres-Jaén, María Josefa[et al.] (2023)
Current immunoassays for diagnosing betalactam (BL) allergy have limited sensitivity and poor specificity. These include ImmunoCAP, the commercial immunoassay, and the radioallergosorbent test (RAST), a handmade test ... -
Glycomimetic Ligands for C-type Lectin Recognition.
(2023)C-type lectin receptors (CLRs) represent pivotal sensory mechanisms orchestrating the primary immune response via dendritic cells.1 The exploration of non-native ligands as molecular tools for the manipulation of CLRs has ... -
A Peptide/Fullerene Hybrid for Multivalent Recognition of E-Selectin
(2022-06-28)Molecular recognition through ligand-receptor interactions is a very important mechanism for metastatic processes. Among all of them, multivalent protein-carbohydrate interactions play a fundamental role in tumor ... -
Spontaneous [2+2] macrocyclization trhough dynamic covalent aminal bonds
Ruiz-Sanchez, Antonio Jesus; Carbajo, Daniel; Nájera-Albendín, Francisco; Alfonso, Ignacio; Pérez-de-Inestrosa-Villatoro, Ezequiel (2022-06)
Aminals are characterized by the connectivity of two amino groups to the same carbon atom, being the nitrogenated equivalent of acetals. Unlike acetals, aminals have been slightly underexplored in dynamic covalent chemistry ... -
Tailoring two-photon fluorescent probes for pH bioimaging in living cells
Nájera-Albendín, Francisco; Benítez-Martín, Carlos; Guadix-Domínguez, Juan Antonio; Pearson, John R.; Pérez-Pomares, José María; Pérez-de-Inestrosa-Villatoro, Ezequiel[et al.] (2022-06-27)
Fluorescence biosensors are indispensable basic tools in modern biology. These type of molecules allow real-time visualization of biological events inside living cells. Especially important in many of these processes ... -
Diseño de dendrímeros amino-terminales basados en enlaces tipo amidas. Estructuras con menor repulsión estérica y síntesis a gran escala
Pérez-de-Inestrosa-Villatoro, Ezequiel; Nájera-Albendín, Francisco; Morgado, Anjara; Vida-Pol, Yolanda (2022-05-30)
La estructura ramificada y la elevada multivalencia que presentan los dendrímeros los convierten en excelentes compuestos con potenciales aplicaciones en el campo de la biomedicina. En concreto, los dendrímeros con grupos ... -
Dendrímeros antigénicos sobre partículas de sílica para determinar IgE específicas de antibióticos betalactámicos
Matamoros Castellano, Esther; Jiménez, Isabel M.; Gil-Ocaña, Violeta; Mayorga Mayorga, Cristobalina; Doña, Inmaculada; Céspedes Lagos, José Antonio; Montañez-Vega, María Isabel; Vida-Pol, Yolanda; Pérez-de-Inestrosa-Villatoro, Ezequiel; Torres-Cazorla, María Isabel[et al.] (2022)
Los inmunoensayos empleados para el diagnóstico in vitro de alergias a antibióticos betalactámicos actualmente presentan una limitada sensibilidad y pobre especificidad, además de no estar disponibles de forma comercial ... -
Aminonaphthalimide-squaraine dyads: photophysical properties and bioimaging application
Squaraines is an important part of the cyanine family which have high extinction coefficients, sharp absorption bands, and intense fluorescence spectra in the red and near infrared region in solution.[1] The unique electronic ... -
Direct characterization of functional materials by haptenized fluorescent dendrimers for in vitro allergic drug diagnose
Ruiz-Sanchez, Antonio Jesus; Collado-Martín, Daniel; Mayorga Mayorga, Cristobalina; Torres-Jaén, María Josefa; Pérez-de-Inestrosa-Villatoro, Ezequiel (2020-10-01)
β-lactams are the most widely drug prescribed against infections, but they are the most commonly reported medication allergy too. A correct diagnosis of these allergic reactions is crucial to avoid rejecting them by other ... -
Design and synthesis of new dendrons for biomedical applications
Dendrons are excellent multifunctional platforms for many different applications. In particular, the development of multivalent molecular nanostructures, with a well-defined size and shape, has an enormous interest in the ... -
Carbazole-based Diradicals for Dynamic Covalent Chemistry
Ruiz-Delgado, María del Carmen; Hartl, Frantisek; Li, Hongxiang; Sancho-García, Juan C.; Pérez Guardiola, Andrés; Rodríguez-González, Sandra; López-Navarrete, Juan Teodomiro; Hernández-Jolín, Víctor; Badía-Domínguez, María Irene[et al.] (2020-01-29)
Dynamic covalent chemistry (DCC) is focused on the creation of structural scaffolds based on chemical components that interact through strong but reversible bonds. In fact, dynamic covalent bonds receive lot of attention ... -
Syntehsis and use of dendrimeric structures as a tool in biomedicine
Pérez-de-Inestrosa-Villatoro, Ezequiel; Vida-Pol, Yolanda; Molina, Noemi; Morgado, Anjara; Nájera-Albendín, Francisco (2019-10-28)
Specific cell interactions of surfaces grafted dendrimers have been applied to the study of cell adhesion. We have studied also the application of dendrimer-based uneven nanopatterns to evaluate the local RGD surface density ... -
“Off-on” two-photon indolenine probes for pH bioimaging
Benítez-Martín, Carlos; Guadix-Domínguez, Juan Antonio; Pearson, John R.; Nájera-Albendín, Francisco; Pérez-Pomares, José María; Pérez-de-Inestrosa-Villatoro, Ezequiel[et al.] (2019-10-25)
Fluorescence-based biosensors have become an indispensable tool in modern biology. These molecules can be used to monitor processes inside living cells and in real-time. The control of the pH is crucial in multiple biological ... -
RGD-dendritic structures on titanium alloy. Influence in the relationship between bone cells and the metal surface
Molina, Noemí; González-Luque, Ana; Becerra-Ratia, José; Santos-Ruiz, Leonor; Vida-Pol, Yolanda; Pérez-de-Inestrosa-Villatoro, Ezequiel[et al.] (2019-09-18)
Prosthetic implants are used in surgical procedures to replace a joint (hip or knee) allowing the functional recovery of the patient. Prostheses are usually made of titanium alloys. However, the lack of chemical and ... -
Synthesis and Biological Evaluation of Depudecin Analogues
Cheng-Sánchez, Iván; Carrillo Fernández, Paloma; García-Ruiz, Cristina; Martínez-Póveda, Beatriz Amparo; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel; Sarabia-García, Francisco Ramón[et al.] (2019-09-18)
(-)-Depudecin (1) (Figure 1), isolated from the culture broths of the fungus Alternaria brassicicola,1 and later, from the weed pathogen Nimbya scirpicola,2 has been identified as a selective inhibitor of histone deacetylases ... -
Synthesis of new bengamide analogues and encapsulation into thermo-responsive magnetic nanoparticles
(2019-09-16)The development and identification of new antitumoral drugs has become a research area of great interest and maximum priority. Firstly, to overcome the secondary effects frequently shown by current antitumorals and, secondly, ... -
New Approaches in the Manufacture of Biomaterials for Betalactam Allergic Diagnose
Collado-Martín, Daniel; Pérez-de-Inestrosa-Villatoro, Ezequiel; Ruiz-Sanchez, Antonio Jesus; Mayorga Mayorga, Cristobalina; Torres-Jaén, María Josefa (2019-09-11)
Betalactams are the most widely utilized drugs against infections but are the primary cause of allergic reactions to antibiotic drugs. REF1 An accurate diagnosis of these allergic reactions to betalactams is crucial to ... -
Pt(II)-dendrimers as bio-imaging marker for bacteria in two-photon excitation microscopy
Vida-Pol, Yolanda; Molina, Noemi; Cnudde, Marvin; Guadix-Domínguez, Juan Antonio; Pérez-Pomares, José María; Strassert, Cristian A.; Pérez-de-Inestrosa-Villatoro, Ezequiel[et al.] (2019-07-25)
The use of luminescent markers based on metal complexes in two-photon excitation microscopy techniques are of great interest in the field of bioimaging. However, despite the excellent luminescent properties of Pt(II) ... -
Synthesis of New Analogues of the Bengamides to encapsulate in magnetic nanoparticles
Ortega Rodríguez, Alicia; Porras Alcalá, Cristina; Contreras-Cáceres, Rafael; López-Romero, Juan Manuel; Melguizo, Consolación; Prados, José Carlos[et al.] (2019-05-15)
The development and identification of new antitumoral has become a research area of great interest and maximum priority due to secondary effects of current antitumoral and the appearance of tumours resistant to these agents. ...