Envíos recientes

  • Design and synthesis of new molecules based on indolium derivatives for two-photon absorption bioimaging applications 

    Benítez-Martín, Carlos; Nájera, Francisco; Pérez-Inestrosa, Ezequiel (2018-11-15)
    Bioimaging is the visualization of biological processes in real time, interfering as less as possible with these and using non-invasive methods. Among others, fluorescence methods have acquired a very important role in ...
  • Synthesis and biological activity of a new class of antitumor cyclopeptides based on the solomonamides 

    Cheng-Sánchez, Iván; Carrillo, Paloma; Martínez-Poveda, Beatriz; Quesada, Ana R.; Medina, MIguel A.; [et al.] (2018-10-15)
    Solomonamides A (1) and B (2) are novel natural products recently isolated from the marine sponge Theonella swinhoei [1]. Preliminary structural studies revealed an unprecedented cyclic peptide type structure. Interestingly, ...
  • Aminonaphtamiline-squaraine dyad: photophysical properties and bioimaging application 

    Collado, Daniel (2018-09-19)
    Squaraines is an important part of the cyanine family which have high extinction coefficients, sharp absorption bands, and intense fluorescence spectra in the red and near infrared region in solution.[1] The unique electronic ...
  • Tuning pKa in new molecules based on indolines for two-photon absorption bioimaging applications 

    Benitez-Martin, Carlos; Najera-Albendin, Francisco; Perez-de-Inestrosa-Villatoro, Ezequiel (Real Sociedad Española de Química, 2018-06-20)
    Fluorescence-based biosensors have become essential tools for modern biology, allowing real-time monitoring of biological processes within living cells. The differences between pH play a significant role in multiple ...
  • Detecting hydroxyl radical with a new two-photon fluorescent probe in living cells 

    Najera-Albendin, Francisco; Benitez-Martin, Carlos; Guadix, Juan Antonio; Perez-Pomares, Jose Maria; Perez-de-Inestrosa-Villatoro, Ezequiel (Real Sociedad Española de Química, 2018-06-20)
    Reactive oxygen species (ROS) are known to be involved in the onset and development of multiple diseases, including cancer, cardiovascular diseases, neurodegenerative diseases and diabetes among others. Generation of ROS ...
  • Diseño y síntesis de nuevos dendrímeros y dendrones. Aplicaciones en regeneración tisular 

    Vida-Pol, Yolanda; Molina, Noemi; Morgado, Anjara; Collado, Daniel; Najera-Albendin, Francisco; [et al.] (2018-03-06)
    Los dendrímeros han generado un enorme interés debido a su particular estructura ramificada y su multivalencia. La extensa investigación que se ha llevado a cabo sobre este tipo de macromoléculas ha demostrado la naturaleza ...
  • Diseño y síntesis de nuevos dendrímeros 

    Morgado, Anjara; Molina, Noemi; Collado, Daniel; Najera-Albendin, Francisco; Vida-Pol, Yolanda; [et al.] (2018-03-06)
    Los dendrímeros son excelentes plataformas multifuncionales para una gran cantidad de diferentes aplicaciones. En particular, el desarrollo de nanoestructuras moleculares multivalentes, con tamaño y forma bien definida, ...
  • Diseño y síntesis de nuevos dendrones para aplicaciones biomédicas 

    Molina, Noemi; Morgado, Anjara; Collado, Daniel; Najera-Albendin, Francisco; Vida-Pol, Yolanda; [et al.] (2018-03-06)
    Los dendrímeros han sido empleados en una gran variedad de aplicaciones, entre las que destacan las del campo de la biomedicina. Estas macromoléculas multivalentes ofrecen la posibilidad de incorporar múltiples funcionalidades ...
  • New molecules based indolium for two-photon absortion bioimaging applications 

    Benitez-Martin, Carlos; Pérez-Inestrosa, Ezequiel; Nájera, Francisco (Universidad de Extremadura, 2017)
    The development of organic materials with 2PA has attracted intensive attention in the past two decades. In two-photon bio-imaging applications the design of the chromophore requires to have a good cross-section and good ...
  • Hybrid pH-Responsive Au@p4VP Microgels as Platform for Selective SERS Analysis 

    Contreras Cáceres, Rafael (2017-09-21)
    We present the synthesis a of pH-responsive core@shell hybrid microgel. This colloidal system is formed by a 55 nm Au core individually covered by a polymeric pH-sensitive shell of poly(4-vinylpyridine), that we denote as ...
  • Synthesis and study of biological activity of tetrahydro-1H-[3]-benzazepines 

    Lucena-Serrano, Ana; Lucena Serrano, Cristina; López-Romero, Juan Manuel; Díaz, Amelia; Valpuesta-Fernandez, Maria (2017-07-20)
    The 3-Benzazepines are an important class of compounds in drug discovery due to their biological activity such as analgesic, antihypertensive or anticancer properties as well as dopaminergic or antidopaminergic activity. ...
  • Synthesis of bioactive compounds. Studies of their attachment to nanoparticles 

    Lucena-Serrano, Cristina; Lucena-Serrano, Ana; López-Romero, Juan Manuel; Díaz, Amelia; Valpuesta-Fernandez, Maria (2017-07-20)
    The 1-aryl tetrahydroisoquinolines have attracted great attention in medicinal chemistry due to their biological activity. These compounds present antitumor, anti-HIV and antibacterial activities. Several analogues of ...
  • Synthesis of New Analogues of the Bengamides: Peptidyl Bengamides and Molecular Probes 

    Aguera-Suárez, Ana María; Porras Alcalá, Cristina; Guerreo Vásquez, Guillermo A.; Cheng-Sánchez, Iván; Sarabia, Francisco (2017-07-20)
    Isolated from sponges of the Jaspidae family, first members where discovered in 1986. The bengamides represent an interesting and unprecedented family of natural products that displayed striking antitumor activities [1]. ...
  • Total synthesis of depudecin and analogues via an olefin cross-metathesis based strategy 

    Cheng Sánchez, Iván; Sarabia, Francisco (2017-07-20)
    (-)-Depudecin (1), isolated from the culture broths of the fungus Alternaria brassicicola [1], has been identified as a selective inhibitor of histone deacetylases (HDAC) with an IC50 in the low μM range. In contrast to ...
  • Synthesis of Molecular Tripods Functionalized with Thioacetate Groups. Model Molecules for Gold Substrates Nanostructuration 

    Sánchez-Molina, María (2017-07-11)
    Self-assembled monolayers (SAMs) of thiols on gold surfaces have attracted widespread interest as they can serve as structural and/or functional parts of biosensors, drug-delivery systems, electronics devices, among other ...
  • Managing with (fluorescent)-biomimetic dendrimers 

    Perez-Inestrosa, Ezequiel; Vida-Pol, Yolanda; Collado, Daniel; Najera, Francisco; Mesa-Antunez, Pablo; [et al.] (2017-06-30)
    Dendrimers that are modified through their peripheral groups have been employed for many biomedical purposes. Diagnosis via specific interactions with target proteins is one of the objectives that has been given more ...
  • Two-Photon Fluorescence As Tool For Imaging In Cells 

    Collado, Daniel (2017-06-30)
    Fluorescent probes are essential tools for studying biological systems. The last decade has witnessed particular interest in the development of two-photon excitable probes, due to their advantageous features in tissue ...
  • Synthesis and applications in biomedicine of new dendrimeric structures 

    Perez-Inestrosa, Ezequiel (2017-06-20)
    Specific cell interactions of surfaces grafted dendrimers have been applied to the study of cell adhesion. We have studied also the application of dendrimer-based uneven nanopatterns to evaluate the local RGD surface density ...
  • Comparative study of dopaminergic activity of tetrahydro-1H-[3]-benzazepines and their precursors 

    Valpuesta-Fernandez, Maria; Lucena-Serrano, Cristina; Rivera, Alicia; Contreras-Cáceres, Rafael; López-Romero, Juan Manuel; [et al.] (2016-10-14)
    The discovery of the tetrahydro-1H-[3]-benzazepine SCH23390 [1], represented one of the most important advances in the study of dopaminergic receptors due to their behavior as a selective D1 receptor antagonist. The high ...
  • Study and characterization of modified silicon surfaces with organic molecules 

    Valpuesta-Fernandez, Maria; Sánchez-Molina, María; Lucena-Serrano, Ana; Contreras-Cáceres, Rafael; López-Romero, Juan Manuel; [et al.] (2016-10-14)
    Nanostructured thin films and subsequent biofunctionalization of silicon substrates are essential for the development of biosensors devices. The formation of organic monolayers on silicon substrates via Si-C bound allows ...

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