• Carbazole-based Diradicals for Dynamic Covalent Chemistry 

      Ruíz-Delgado, María del Carmen; Hartl, Franktišek; Li, Hongxiang; Sancho García, Juan Carlos; Pérez Guardiola, Andrés; [et al.] (2020-01-29)
      Dynamic covalent chemistry (DCC) is focused on the creation of structural scaffolds based on chemical components that interact through strong but reversible bonds. In fact, dynamic covalent bonds receive lot of attention ...
    • Comparative study of dopaminergic activity of tetrahydro-1H-[3]-benzazepines and their precursors 

      Valpuesta-Fernandez, Maria; Lucena-Serrano, Cristina; Rivera-Ramirez, Alicia; Contreras-Cáceres, Rafael; López-Romero, Juan Manuel; [et al.] (2016-10-14)
      The discovery of the tetrahydro-1H-[3]-benzazepine SCH23390 [1], represented one of the most important advances in the study of dopaminergic receptors due to their behavior as a selective D1 receptor antagonist. The high ...
    • Dendrimers-modified solid supports: towards nanostructures materials for clinical diagnostic 

      Vida-Pol, Yolanda; Collado, Daniel; Najera-Albendin, Francisco; Montañe, M I; Perez-Inestrosa, E; [et al.] (2013-09-25)
      The design and synthesis of new materials for biomedical applications is a high-priority research topic in a number of biomedical areas. The rapid development of nanotechnology over the past few decades has created wide ...
    • Design and synthesis of new dendrons for biomedical applications 

      Morgado, Anjara; Vida-Pol, Yolanda; Perez-Inestrosa, Ezequiel (2020-03-30)
      Dendrons are excellent multifunctional platforms for many different applications. In particular, the development of multivalent molecular nanostructures, with a well-defined size and shape, has an enormous interest in the ...
    • Design and synthesis of new molecules based on indolium derivatives for two-photon absorption bioimaging applications 

      Benítez-Martín, Carlos; Najera-Albendin, Francisco; Pérez-Inestrosa, Ezequiel (2018-11-15)
      Bioimaging is the visualization of biological processes in real time, interfering as less as possible with these and using non-invasive methods. Among others, fluorescence methods have acquired a very important role in ...
    • Design of multi-haptenized dendrimeric-antigens for in vitro IgE recognition 

      Najera-Albendin, Francisco; Montañez, María Isabel; Ruiz-Sánchez, Antonio Jesús; Vida-Pol, Yolanda; Collado, Daniel; [et al.] (2014-06-12)
      Reactions mediated by the Immunoglobulin E (IgE) involved a high number of allergic drug responses, ranging from simple skin symptoms to anaphylactic shock.1 In order to emulate the recognition process working in vivo, ...
    • Detecting hydroxyl radical with a new two-photon fluorescent probe in living cells 

      Najera-Albendin, Francisco; Benitez-Martin, Carlos; Guadix, Juan Antonio; Perez-Pomares, Jose Maria; Perez-de-Inestrosa-Villatoro, Ezequiel (Real Sociedad Española de Química, 2018-06-20)
      Reactive oxygen species (ROS) are known to be involved in the onset and development of multiple diseases, including cancer, cardiovascular diseases, neurodegenerative diseases and diabetes among others. Generation of ROS ...
    • Diastereoselective synthesis of chiral amines by imines alkylation 

      Díaz, Amelia; Muñoz, Carmen; Sánchez, María; Valpuesta-Fernandez, Maria (2013-10-03)
      En esta comunicación se aborda la síntesis de aminas quirales utilizando como agente alquilante trietilborano.
    • Direct characterization of functional materials by haptenized fluorescent dendrimers for in vitro allergic drug diagnose 

      Ruiz-Sanchez, Antonio J.; Collado, Daniel; Mayorga, Cristobalina; Torres, Maria J.; Perez-Inestrosa, Ezequiel (2020-10-01)
      β-lactams are the most widely drug prescribed against infections, but they are the most commonly reported medication allergy too. A correct diagnosis of these allergic reactions is crucial to avoid rejecting them by other ...
    • Diseño y síntesis de nuevos dendrímeros 

      Morgado, Anjara; Molina, Noemi; Collado, Daniel; Najera-Albendin, Francisco; Vida-Pol, Yolanda; [et al.] (2018-03-06)
      Los dendrímeros son excelentes plataformas multifuncionales para una gran cantidad de diferentes aplicaciones. En particular, el desarrollo de nanoestructuras moleculares multivalentes, con tamaño y forma bien definida, ...
    • Diseño y síntesis de nuevos dendrímeros y dendrones. Aplicaciones en regeneración tisular 

      Vida-Pol, Yolanda; Molina, Noemi; Morgado, Anjara; Collado, Daniel; Najera-Albendin, Francisco; [et al.] (2018-03-06)
      Los dendrímeros han generado un enorme interés debido a su particular estructura ramificada y su multivalencia. La extensa investigación que se ha llevado a cabo sobre este tipo de macromoléculas ha demostrado la naturaleza ...
    • Diseño y síntesis de nuevos dendrones para aplicaciones biomédicas 

      Molina, Noemi; Morgado, Anjara; Collado, Daniel; Najera-Albendin, Francisco; Vida-Pol, Yolanda; [et al.] (2018-03-06)
      Los dendrímeros han sido empleados en una gran variedad de aplicaciones, entre las que destacan las del campo de la biomedicina. Estas macromoléculas multivalentes ofrecen la posibilidad de incorporar múltiples funcionalidades ...
    • Energy transfer in Aminonaphthalimide-BODIPY dyads upon one and two photons excitation 

      Collado, Daniel; Vida-Pol, Yolanda; Najera-Albendin, Francisco; Pérez-Inestrosa, Ezequiel (2014-07-03)
      BODIPY dyes are nowadays widely commercialized chromophores that have attracted immense interest as versatile tools in biological chemistry [1]. However, the generally very small Stokes shifts of BODIPY dyes may cause ...
    • Fijación de dendrímeros antigénicos en superficies para determinación de IgE 

      Vida-Pol, Yolanda; Montañez, María Isabel; Mesa, Pablo; Collado, Daniel; Najera-Albendin, Francisco; [et al.] (2016-02-15)
      Actualmente, el diseño de nuevos materiales con potenciales aplicaciones biomédicas es de gran importancia , sobre todo para su uso directo en diagnóstico clínico . En particular, los dispositivos que ...
    • Hybrid pH-Responsive Au@p4VP Microgels as Platform for Selective SERS Analysis 

      Contreras Cáceres, Rafael (2017-09-21)
      We present the synthesis a of pH-responsive core@shell hybrid microgel. This colloidal system is formed by a 55 nm Au core individually covered by a polymeric pH-sensitive shell of poly(4-vinylpyridine), that we denote as ...
    • Intramolecular [3+2] cycloaddition of azido-unsaturated esters derived of monosaccharides 

      Pino-Gonzalez, Maria Soledad; Romero-Carrasco, Antonio; Calvo-Losada, Saturnino; Quirante-Sanchez, Jose Joaquin (2013-11-05)
      Iminosugars have been shown to be very potent inhibitors of glycosidases and glycolsyltransferases. Due to their ability to resemble the transition states of the sugars involved in these processes, a variety of m onocyclic ...
    • Intramolecular [3+2] Cycloaddition of Fused Azolo-Azepanes from Azido Monosaccharides Derivatives 

      Pino-Gonzalez, Maria Soledad; Romero-Carrasco, Antonio; Calvo-Losada, Saturnino; Quirante-Sanchez, Jose Joaquin (Centro Investigaciones Biológicas, 2016)
      Síntesis de bicíclicos compuestos empleando epoxiamidas como material de partida. Obtención de tetrazolo azepanos con posible actividad biológica.
    • Lipid and Janus nanoparticles for active delivery 

      López-Romero, Juan Manuel (2014-06-12)
      The following synthesis is based on the paper „Production of large quantities of „Janus“ nanoparticles using wax-in-water emulsions“ published by Ravaine et al.[1]In two beakers, 0.2 g of the synthesized silica particles ...
    • Managing with (fluorescent)-biomimetic dendrimers 

      Perez-Inestrosa, Ezequiel; Vida-Pol, Yolanda; Collado, Daniel; Najera-Albendin, Francisco; Mesa-Antunez, Pablo; [et al.] (2017-06-30)
      Dendrimers that are modified through their peripheral groups have been employed for many biomedical purposes. Diagnosis via specific interactions with target proteins is one of the objectives that has been given more ...
    • New Approaches in the Manufacture of Biomaterials for Betalactam Allergic Diagnose 

      Collado, Daniel; Perez-Inestrosa, Ezequiel; Ruiz-Sanchez, Antonio Jesus; Mayorga, Cristobalina; Torres-Jaen, Maria Josefa (2019-09-11)
      Betalactams are the most widely utilized drugs against infections but are the primary cause of allergic reactions to antibiotic drugs. REF1 An accurate diagnosis of these allergic reactions to betalactams is crucial to ...