• Sistema fluorescentes multifotónicos con aplicaciones en bioimagen 

      Collado, Daniel; Perez-Inestrosa, Ezequiel; Vida-Pol, Yolanda; Najera-Albendin, Francisco; Ramon, Patricia; [et al.] (2013-09-20)
      Los colorantes y las sondas fluorescentes son componentes clave en el estudio de muestras biológicas mediante microscopía de fluorescencia. Mientras que muchos colorantes fluorescentes disponibles comercialmente han sido ...
    • Spontaneous [2+2] macrocyclization trhough dynamic covalent aminal bonds 

      Ruiz-Sánchez, Antonio Jesús; Carbajo, Daniel; Najera-Albendin, Francisco; Alfonso, Ignacio; Perez-de-Inestrosa-Villatoro, Ezequiel (2022-06)
      Aminals are characterized by the connectivity of two amino groups to the same carbon atom, being the nitrogenated equivalent of acetals. Unlike acetals, aminals have been slightly underexplored in dynamic covalent chemistry ...
    • Study and characterization of modified silicon surfaces with organic molecules 

      Valpuesta-Fernandez, Maria; Sánchez-Molina, María; Lucena-Serrano, Ana; Contreras-Cáceres, Rafael; López-Romero, Juan Manuel; [et al.] (2016-10-14)
      Nanostructured thin films and subsequent biofunctionalization of silicon substrates are essential for the development of biosensors devices. The formation of organic monolayers on silicon substrates via Si-C bound allows ...
    • Syntehsis and use of dendrimeric structures as a tool in biomedicine 

      Perez-Inestrosa, Ezequiel; Vida-Pol, Yolanda; Molina, Noemi; Morgado, Anjara; Najera-Albendin, Francisco (2019-10-28)
      Specific cell interactions of surfaces grafted dendrimers have been applied to the study of cell adhesion. We have studied also the application of dendrimer-based uneven nanopatterns to evaluate the local RGD surface density ...
    • Synthesis and applications in biomedicine of new dendrimeric structures 

      Perez-Inestrosa, Ezequiel (2017-06-20)
      Specific cell interactions of surfaces grafted dendrimers have been applied to the study of cell adhesion. We have studied also the application of dendrimer-based uneven nanopatterns to evaluate the local RGD surface density ...
    • Synthesis and biological activity of a new class of antitumor cyclopeptides based on the solomonamides 

      Cheng-Sánchez, Iván; Carrillo, Paloma; Martínez-Poveda, Beatriz; Quesada, Ana R.; Medina, Miguel Ángel; [et al.] (2018-10-15)
      Solomonamides A (1) and B (2) are novel natural products recently isolated from the marine sponge Theonella swinhoei [1]. Preliminary structural studies revealed an unprecedented cyclic peptide type structure. Interestingly, ...
    • Synthesis and Biological Evaluation of Depudecin Analogues 

      Cheng-Sánchez, Iván; Carrillo, Paloma; García-Ruiz, Cristina; Martínez-Poveda, Beatriz; Quesada, Ana R.; [et al.] (2019-09-18)
      (-)-Depudecin (1) (Figure 1), isolated from the culture broths of the fungus Alternaria brassicicola,1 and later, from the weed pathogen Nimbya scirpicola,2 has been identified as a selective inhibitor of histone deacetylases ...
    • Synthesis and Biomedical aplications of BAPAD: Bisaminoalkylpolyamide Dendrimers 

      Perez-Inestrosa, Ezequiel; Ruiz-Sanchez, Antonio Jesus; Vida-Pol, Yolanda; Collado, Daniel; Najera-Albendin, Francisco; [et al.] (2014-02-06)
      A new class of Dendrimeric Systems (Dendrimers and Dendrons) and the study of their properties in molecular recognition processes are presented. These Dendrimers (BAPAD: BisAminoalkylPolyAmideDendrimers), are designed to ...
    • Synthesis and study of biological activity of tetrahydro-1H-[3]-benzazepines 

      Lucena-Serrano, Ana; Lucena-Serrano, Cristina; López-Romero, Juan Manuel; Díaz, Amelia; Valpuesta-Fernandez, Maria (2017-07-20)
      The 3-Benzazepines are an important class of compounds in drug discovery due to their biological activity such as analgesic, antihypertensive or anticancer properties as well as dopaminergic or antidopaminergic activity. ...
    • Synthesis of bioactive compounds. Studies of their attachment to nanoparticles 

      Lucena-Serrano, Cristina; Lucena-Serrano, Ana; López-Romero, Juan Manuel; Díaz, Amelia; Valpuesta-Fernandez, Maria (2017-07-20)
      The 1-aryl tetrahydroisoquinolines have attracted great attention in medicinal chemistry due to their biological activity. These compounds present antitumor, anti-HIV and antibacterial activities. Several analogues of ...
    • Synthesis of fluorescent BAPAD dendrimeric structrures for biomedical applications 

      Mesa-Antunez, Pablo; Collado, Daniel; Najera-Albendin, Francisco; Perez-Inestrosa, Ezequiel (2014-02-03)
      In this work, we present the synthesis and characterization of BAPAD1 fluorescent Dendrimeric-Antigens (DeAn), to study the dendritic cell maturation as a test to detect drug allergy reactions. Recently our research group ...
    • Synthesis of fluorescent dendrimeric antigen efficiently internalized by human dendritic cells 

      Mesa-Antunez, Pablo; Collado, Daniel; Vida-Pol, Yolanda; Najera-Albendin, Francisco; Fernandez, Tahia; [et al.] (Servicio de Publicaciones de la Universidad de Huelva, 2016)
      A new fluorescent dendrimeric antigen (DeAn) based on a dendron with amoxicilloyl terminal groups has been synthetized. The synthesis implies a novel class of all-aliphatic polyamide dendrimer (BisAminoalkylPolyAmide ...
    • Synthesis of fused tetrazolo iminosugars from azido monosaccharide derivatives 

      Pino-Gonzalez, Maria Soledad (Universidad de la Rioja, 2014)
      Synthesis of fused tetrazolo iminosugars from azido monosaccharide derivatives
    • Synthesis of Molecular Tripods Functionalized with Thioacetate Groups. Model Molecules for Gold Substrates Nanostructuration 

      Sánchez-Molina, María (2017-07-11)
      Self-assembled monolayers (SAMs) of thiols on gold surfaces have attracted widespread interest as they can serve as structural and/or functional parts of biosensors, drug-delivery systems, electronics devices, among other ...
    • Synthesis of New Analogues of the Bengamides to encapsulate in magnetic nanoparticles 

      ORTEGA RODRIGUEZ, ALICIA; PORRAS ALCALA, CRISTINA; Contreras-Cáceres, Rafael; López-Romero, Juan Manuel; MELGUIZO, CONSOLACION; [et al.] (2019-05-15)
      The development and identification of new antitumoral has become a research area of great interest and maximum priority due to secondary effects of current antitumoral and the appearance of tumours resistant to these agents. ...
    • Synthesis of New Analogues of the Bengamides: Peptidyl Bengamides and Molecular Probes 

      Aguera-Suárez, Ana María; Porras Alcalá, Cristina; Guerreo Vásquez, Guillermo A.; Cheng-Sánchez, Iván; Sarabia, Francisco (2017-07-20)
      Isolated from sponges of the Jaspidae family, first members where discovered in 1986. The bengamides represent an interesting and unprecedented family of natural products that displayed striking antitumor activities [1]. ...
    • Synthesis of new bengamide analogues and encapsulation into thermo-responsive magnetic nanoparticles 

      Porras Alcalá, Cristina (2019-09-16)
      The development and identification of new antitumoral drugs has become a research area of great interest and maximum priority. Firstly, to overcome the secondary effects frequently shown by current antitumorals and, secondly, ...
    • Synthesis of the Macrocylic Core of the Solomonamides, a New Class of Cyclopeptides of Marine Origin 

      Cheng-Sánchez, Iván (2016-09-29)
      Se describe estudios sintéticos dirigidos hacia la síntesis total de solomonamides, una nueva clase de ciclopéptidos de origen marino que presentan interesantes propiedades biológicas. La aproximación sintética se basó en ...
    • Tailoring two-photon fluorescent probes for pH bioimaging in living cells 

      Najera-Albendin, Francisco; Benítez-Martín, Carlos; Guadix, Juan A.; Pearson, John R.; Perez-Pomares, Jose Maria; [et al.] (2022-06-27)
      Fluorescence biosensors are indispensable basic tools in modern biology. These type of molecules allow real-time visualization of biological events inside living cells. Especially important in many of these processes ...
    • Thermorresponsive magnetic nanoparticles as target drug delivery for cancer treatment 

      ORTEGA RODRIGUEZ, ALICIA; PORRAS ALCALA, CRISTINA; Contreras-Cáceres, Rafael; López-Romero, Juan Manuel; MELGUIZO, CONSOLACION; [et al.] (2019-05-15)
      In this research, temperature sensitive microgels with magnetic core for controlled release of 5-fluoruracil was synthesized. Magnetic nanoparticles (Fe3O4) were prepared by coprecipitation method and the surface was ...