• Thermorresponsive magnetic nanoparticles as target drug delivery for cancer treatment 

      ORTEGA RODRIGUEZ, ALICIA; PORRAS ALCALA, CRISTINA; Contreras-Cáceres, Rafael; López-Romero, Juan Manuel; MELGUIZO, CONSOLACION; [et al.] (2019-05-15)
      In this research, temperature sensitive microgels with magnetic core for controlled release of 5-fluoruracil was synthesized. Magnetic nanoparticles (Fe3O4) were prepared by coprecipitation method and the surface was ...
    • Total synthesis of depudecin and analogues via an olefin cross-metathesis based strategy 

      Cheng-Sánchez, Iván; Sarabia, Francisco (2017-07-20)
      (-)-Depudecin (1), isolated from the culture broths of the fungus Alternaria brassicicola [1], has been identified as a selective inhibitor of histone deacetylases (HDAC) with an IC50 in the low μM range. In contrast to ...
    • Tripod-shaped penta (p-phenylene)s for the functionalization of silicon surfaces 

      Sánchez-Molina, María Sánchez-Molina,; Contreras-Cáceres, Rafael; Diaz, Amelia; Valpuesta-Fernandez, Maria; López-Romero, Juan Manuel (2016-03-31)
      In order to obtain nanostructured thin films to be used in biosensor devices, several chemical functionalization methods have been developed, such as Click chemistry or Suzuki carbon-carbon coupling reactions on surfaces.1 ...
    • Tuning pKa in new molecules based on indolines for two-photon absorption bioimaging applications 

      Benitez-Martin, Carlos; Najera-Albendin, Francisco; Perez-de-Inestrosa-Villatoro, Ezequiel (Real Sociedad Española de Química, 2018-06-20)
      Fluorescence-based biosensors have become essential tools for modern biology, allowing real-time monitoring of biological processes within living cells. The differences between pH play a significant role in multiple ...
    • Two-Photon Fluorescence As Tool For Imaging In Cells 

      Collado, Daniel (2017-06-30)
      Fluorescent probes are essential tools for studying biological systems. The last decade has witnessed particular interest in the development of two-photon excitable probes, due to their advantageous features in tissue ...