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dc.contributor.authorMedina, Miguel Ángel 
dc.contributor.authorRodriguez-Quesada, Ana Maria 
dc.contributor.authorCárdenas, Casimiro
dc.date.accessioned2013-10-29T12:13:04Z
dc.date.available2013-10-29T12:13:04Z
dc.date.issued2013-09-04
dc.identifier.citationLibro de Resúmenes online del XXXVI Congreso SEBBMes_ES
dc.identifier.urihttp://hdl.handle.net/10630/6182
dc.description.abstractAlthough epidemiological studies indicate that coffee consumption is associated with a low incidence of several kinds of cancer, there are still few studies on the anti-tumoral effects of pure bioactive compounds isolated from coffee. The present study aims to identify the modulatory effects of kahweol, an antioxidant diterpene contained in unfiltered coffee, on a panel of human tumor cell lines. Kahweol inhibits tumor cell proliferation and clonogenicity and induces apoptosis in several kinds of human tumor cells, with a special incidence on the estrogen receptor-negative MDA-MB231 human breast cancer cells. In these breast cancer cells, the mentioned effects are accompanied by caspases 3/7 and 9 activation and cytochrome c release, both consistent with an activation of the intrinsic pathway of apoptosis. Kahweol also increases the phosphorylation levels of protein kinase B (AKT) and extracellular-signal-regulated kinase (ERK) observed in MDA-MB-231 cells. We also demonstrate the inhibitory effect of kahweol on the MDA-MB231 cell potential to migrate and to remodel extracellular matrix by targeting matrix metalloproteinase-9 and urokinase-type plasminogen activator, two key molecules involved in this process. Taken together, our data suggest that, indeed, kahweol behaves as an antitumor compound, especially against MDA-MB231 breast cancer cells.es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.publisherSEBBMes_ES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMamas - Cánceres_ES
dc.subjectCafées_ES
dc.subject.otherKahweoles_ES
dc.subject.otherBreast canceres_ES
dc.subject.otherCoffeees_ES
dc.titleThe coffee diterpene kahweol is an antitumoral compound for human estrogen receptor-negative breast cancer cellses_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Cienciases_ES
dc.relation.eventtitleXXXVI Congreso SEBBMes_ES
dc.relation.eventplaceMadrides_ES
dc.relation.eventdateSeptiembre de 2013es_ES


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