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dc.contributor.authorArrabal-García, Pilar María 
dc.contributor.authorVisser, Rick 
dc.contributor.authorCifuentes-Rueda, Manuel 
dc.contributor.authorBecerra-Ratia, José 
dc.contributor.authorJiménez-Enjuto, E.
dc.date.accessioned2013-11-08T08:10:02Z
dc.date.available2013-11-08T08:10:02Z
dc.date.issued2013-11-08
dc.identifier.urihttp://hdl.handle.net/10630/6378
dc.description.abstractThe use of autograft for posterolateral spinal fusion, continue being considered the gold standard for the treatment of spine pathologies. However, due to complications such as donor site morbidity, increased operating time, and limited supply, the use of allograft has become an acceptable practice especially in multisegment arthrodesis or in patients with previous graft harvests. Since their use involves the risk of immune response or disease transmission and fusion rates are not as good as with autogenous bone, a variety of bone graft substitutes are being studied to obtain a better alternative. Osteoinductive growth factors, which initiate the molecular cascade of bone formation and play a key role in the development and regeneration of the skeletal system, have been shown to be effective in numerous animal studies. These molecules must be used in combination with a biomaterial to avoid their dispersion from the application site. On the other hand, it is well known that cultured bone marrow cells, harvested from adult bone marrow, may contribute to the regeneration of bone. Thus, hybrid constructs can be used as alternatives to autologous and allogenic grafts. In this study, we have evaluated different combination of cultured bone marrow cells with recombinant human osteoinductive growth factors, all of them in combination with a natural polimeric carrier, for the promotion of posterolateral spinal fusion in rats. Supported by grants from the Red de Terapia Celular (RD12/0019/0032), Spanish Government BIO2012-34960, and the Andalusian Government (P11-CVI 07245).es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHuesos - Regeneraciónes_ES
dc.subjectIngeniería de tejidoses_ES
dc.subject.otherBMP2es_ES
dc.subject.otherMSCes_ES
dc.subject.otherTissue engineeringes_ES
dc.subject.otherBone regenerationes_ES
dc.titleBone marrow mesenchymal stem cells, collagen scaffold and BMP-2 for rat spinal fusioes_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Cienciases_ES
dc.relation.eventtitleS Europea y Española de Terapia Génica y Celulares_ES
dc.relation.eventplaceMadrides_ES
dc.relation.eventdate25-28 octubre 2013es_ES


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