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dc.contributor.authorPerez-Inestrosa, Ezequiel
dc.contributor.authorRuiz-Sanchez, Antonio Jesus
dc.contributor.authorVida-Pol, Yolanda 
dc.contributor.authorCollado, Daniel 
dc.contributor.authorNajera, Francisco
dc.contributor.authorMesa, Pablo
dc.contributor.authorMorato, Isabel
dc.contributor.authorBarbero, Nekane
dc.date.accessioned2014-02-06T11:13:57Z
dc.date.available2014-02-06T11:13:57Z
dc.date.issued2014-02-06
dc.identifier.urihttp://hdl.handle.net/10630/7005
dc.description.abstractA new class of Dendrimeric Systems (Dendrimers and Dendrons) and the study of their properties in molecular recognition processes are presented. These Dendrimers (BAPAD: BisAminoalkylPolyAmideDendrimers), are designed to present peripheral amino groups and based on a skeletal amide bonds. They will be prepared by iterative condensation of di(beta-amino)acids prepared by reduction of the corresponding azido or nitro compounds. Dendron-like systems will be prepared following the same methodology. The versatility of these dendrimeric structures can be exploited by the dinitroderivative approach, according to the synthetic strategies that can be applied in the dendrimer construction. These dendrimeric structures have been haptenized with the allergenic determinant to Amoxicillin and assayed in RAST inhibition studies letting us check that inhibition occurred, so recognition existed between IgE of patients allergic to Amoxicillin and BAPAD-AXO structures. The introduction of a fluorescent unit (a 1,8-naphthalimide) in a haptenized Dendron structure bound over the surface of cellulose disks allowed a characterization of solid supports for RAST assays, having a new property, fluorescence, to measure the haptenization degree and the reproducibility, and providing also an effective control on the manufacture of the cellulose disks for RAST assays. This material meet all the requirements for it potential use in clinical diagnostic tests.es_ES
dc.description.sponsorshipCTQ2010-20303. Universidad de Málaga. Campus de Excelencia Internacional Andalucía Teches_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDendrímeroses_ES
dc.subjectMacromoléculases_ES
dc.subject.otherDendrímeroses_ES
dc.subject.otherNanomedicinaes_ES
dc.subject.otherDrug allergyes_ES
dc.subject.otherOrganic synthesises_ES
dc.titleSynthesis and Biomedical aplications of BAPAD: Bisaminoalkylpolyamide Dendrimerses_ES
dc.typeinfo:eu-repo/semantics/otheres_ES
dc.centroFacultad de Cienciases_ES
dc.relation.eventtitleIV Encuentro sobre dendrimeros EDEN 4es_ES
dc.relation.eventplaceSantiago de Compostelaes_ES
dc.relation.eventdate23-24/01/2014es_ES


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