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dc.contributor.authorNájera-Albendín, Francisco 
dc.contributor.authorMontañez-Vega, María Isabel 
dc.contributor.authorRuiz-Sanchez, Antonio Jesus
dc.contributor.authorVida-Pol, Yolanda 
dc.contributor.authorCollado-Martín, Daniel 
dc.contributor.authorPérez-de-Inestrosa-Villatoro, Ezequiel 
dc.contributor.authorMayorga Mayorga, Cristobalina
dc.contributor.authorTorres, María José
dc.contributor.authorBlanca Gómez, Miguel
dc.date.accessioned2014-06-12T12:52:17Z
dc.date.available2014-06-12T12:52:17Z
dc.date.issued2014-06-12
dc.identifier.urihttp://hdl.handle.net/10630/7669
dc.descriptionComunicación Orales_ES
dc.description.abstractReactions mediated by the Immunoglobulin E (IgE) involved a high number of allergic drug responses, ranging from simple skin symptoms to anaphylactic shock.1 In order to emulate the recognition process working in vivo, much effort have been made to prepare hapten(drug)-carrier(protein) conjugates attempting to work like the antigen responsible for the allergic drug reaction.2 In our efforts to exploit the dendrimer properties in the interaction with the immunological system,3 we have prepared and characterized a series of G4-PAMAM dendrimers peripherally decorated with the determinant responsible of the allergic response to the β-lactam antibiotic: benzylpenicillin (BPO) or amoxicillin (AXO). Additionally, three multi-haptenized Dendrimeric-Antigens (DeAn) including both epitopes (BPO and AXO) in the same carrier have been prepared. The combination of 1D and 2D-NMR techniques and Molecular Dynamic simulations,4 allow the structural characterization of these new antigens and afford evidences that the composition and the distribution of both haptens on the dendrimer surface play key roles for the IgE-antigen recognition. The immunochemical studies of these DeAn enable to diagnose patients allergic to benzylpenicillin, amoxicillin or to both drugs with a single test. These DeAn provide a significant model to study IgE recognition from patients who suffer an allergic reaction to these -lactam antibiotics.es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectQuímica orgánicaes_ES
dc.subject.otherOrganic Chemistryes_ES
dc.subject.otherDendrimeres_ES
dc.subject.otherIgEes_ES
dc.titleDesign of multi-haptenized dendrimeric-antigens for in vitro IgE recognitiones_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Cienciases_ES
dc.relation.eventtitleXXV Reunión Bienal de Química Orgánicaes_ES
dc.relation.eventplaceAlicante (España)es_ES
dc.relation.eventdate4-6 de junio de 2014es_ES


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