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dc.contributor.authorRuiz-Pérez, M. Victoria
dc.contributor.authorUrdiales, José Luis
dc.contributor.authorSánchez-Jiménez, Francisca
dc.contributor.authorMedina Torres, Miguel Ángel
dc.date.accessioned2014-07-10T11:31:01Z
dc.date.available2014-07-10T11:31:01Z
dc.date.created2014-07
dc.date.issued2014-07-10
dc.identifier.urihttp://hdl.handle.net/10630/7802
dc.description.abstractOrnithine-derived polyamines are essential for cell proliferation, and their levels are elevated in many human tumors. Neuroblastoma, the most frequent extra-cranial solid tumor in children, harbors amplification of n-myc oncogene (which enhances polyamine metabolism) in 25% of the cases. In the present communication, the relevance of n-myc amplification in several metabolic features of human neuroblastoma cell lines is studied. A previously unknown linkage between glycolysis impairment and polyamine reduction, related to n-myc amplification, is unveiled. Results show that glycolysis inhibition is able to trigger signaling events leading to the reduction of N-Myc protein levels and subsequent decrease of both ornithine decarboxylase expression and polyamine levels, accompanied by cell cycle blockade preceding cell death. Metabolism-targeted therapies are emerging as new approaches for cancer treatment. New anti-tumor strategies could take advantage of the direct relationship between glucose deprivation and PA metabolism impairment leading to cell death described in the present work, and its apparent dependence on n-myc amplification in the case of neuroblastoma. Combined therapies targeting glucose metabolism and polyamine synthesis could be effective in the treatment of n-myc amplified tumors.es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. This work has been funded by Grants SAF2011-26518 (Ministerio de Economía y Competitividad, Spain), Excellence Projects CTS-1507 and CVI-06585 (Junta de Andalucía, Spain) and BIO-267 (fondos PAIDI, Junta de Andalucía, Spain). MVRP was the recipient of a FPU long-term fellowship (Ministerio de Educación, Cultura y Deporte, Spain) and a “III Plan Propio de Investigación” short-term fellowship (University of Málaga). CIBERER is an initiative of Instituto de Salud Carlos III. This communication has the support of a travel grant "Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech".es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectNeuroblastomaes_ES
dc.subjectPoliaminas - Metabolismoes_ES
dc.subject.otherPolyamine metabolismes_ES
dc.subject.otherGlycolysises_ES
dc.subject.otherN-myc oncogenees_ES
dc.titleSensitivity of polyamine metabolism to glucose deprivation is increased in neuroblastoma cells with N-myc amplificationes_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Cienciases_ES
dc.relation.eventtitleBeatson International Cancer Conference "Powering the Cancer Machine"es_ES
dc.relation.eventplaceGlasgow (Reino Unido)es_ES
dc.relation.eventdateJulio de 2014es_ES


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