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    •   RIUMA Principal
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    • Fisiología Humana, Histología Humana, Anatomía Patológica y Educación Física y Deportiva - (FHEFD)
    • FHEFD - Contribuciones a congresos científicos
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    •   RIUMA Principal
    • Investigación
    • Fisiología Humana, Histología Humana, Anatomía Patológica y Educación Física y Deportiva - (FHEFD)
    • FHEFD - Contribuciones a congresos científicos
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    Galanin N-Terminal fragment (1-15) induces a stronger effect than Galanin in depression- and anxiety- like related behavioural tests in rats.

    • Autor
      Millon-Peñuela, CarmeloAutoridad Universidad de Málaga; Narváez, ManuelAutoridad Universidad de Málaga; Flores-Burgess, AntonioAutoridad Universidad de Málaga; Parrado-Romero, ConcepcionAutoridad Universidad de Málaga; Puigcerver-Martinez, AraceliAutoridad Universidad de Málaga; Coveñas, Rafael; Santin-Nuñez, Luis JavierAutoridad Universidad de Málaga; Borroto-Escuela, Dasiel; Fuxe, Kjell; Narváez, José ÁngelAutoridad Universidad de Málaga; Díaz-Cabiale, ZaidaAutoridad Universidad de Málaga
    • Fecha
      2014-07-16
    • Palabras clave
      Depresión mental; Neurorreceptores
    • Resumen
      Galanin (GAL) and GAL Receptors are implicated in anxiety- and depression- related behaviours. The GAL N-terminal fragment (1-15) [GAL(1-15)] also induces depressant- and anxiogenic- like actions. In this work, we have compared the effects of GAL and GAL(1-15) in depression- and anxiety- related behaviours using the Forced Swimming Test (FST) and the Open Field Test (OFT). In the first set of experiments, rats (n=8-10) were injected with GAL 3nmol, GAL(1-15) 3nmol or vehicle 15min before the FST. Two sessions were conducted: a 15min. pre-test followed 24h later by 5min. test. The duration of immobility and climbing were recorded during the test. In the second set, rats (n=6-10) were injected with GAL 3nmol, GAL(1-15) 3nmol or vehicle 15min before the OFT. Time and entries in the central square during 300 Sec. were scored. In the FST, the increase in the immobility induced by GAL(1-15) was significantly higher (p<0.01) than the one induced by GAL. In the climbing response GAL(1-15) also induced a significantly stronger decrease (p<0.05) in climbing compared with GAL. In the OFT, GAL(1-15) significantly decrease the number of entries (p<0.01) and time (p<0.05) in centre while GAL lacks of effect. These results indicate that GAL(1-15) has more powerful effects than GAL in depression-like behaviour in the FST and anxiogenic-like effects in the OFT. These findings may give the basis for the development of novel therapeutic drugs targeting GAL(1-15) system for treatment of depression and anxiety disorders.
    • URI
      http://hdl.handle.net/10630/7853
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    Ficheros
    FENS 2014 Carmelo .pdf (69.91Kb)
    Colecciones
    • FHEFD - Contribuciones a congresos científicos

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    REPOSITORIO INSTITUCIONAL UNIVERSIDAD DE MÁLAGA
    REPOSITORIO INSTITUCIONAL UNIVERSIDAD DE MÁLAGA