Mostrar el registro sencillo del ítem

dc.contributor.authorMillón, Carmelo
dc.contributor.authorNarváez, Manuel 
dc.contributor.authorFlores-Burgess, Antonio
dc.contributor.authorParrado-Romero, Concepcion 
dc.contributor.authorPuigcerver-Martinez, Araceli 
dc.contributor.authorCoveñas, Rafael
dc.contributor.authorSantin-Nuñez, Luis Javier 
dc.contributor.authorBorroto-Escuela, Dasiel
dc.contributor.authorFuxe, Kjell
dc.contributor.authorNarváez, José Ángel 
dc.contributor.authorDíaz-Cabiale, Zaida 
dc.date.accessioned2014-07-16T11:03:35Z
dc.date.available2014-07-16T11:03:35Z
dc.date.created2014-07
dc.date.issued2014-07-16
dc.identifier.urihttp://hdl.handle.net/10630/7853
dc.description.abstractGalanin (GAL) and GAL Receptors are implicated in anxiety- and depression- related behaviours. The GAL N-terminal fragment (1-15) [GAL(1-15)] also induces depressant- and anxiogenic- like actions. In this work, we have compared the effects of GAL and GAL(1-15) in depression- and anxiety- related behaviours using the Forced Swimming Test (FST) and the Open Field Test (OFT). In the first set of experiments, rats (n=8-10) were injected with GAL 3nmol, GAL(1-15) 3nmol or vehicle 15min before the FST. Two sessions were conducted: a 15min. pre-test followed 24h later by 5min. test. The duration of immobility and climbing were recorded during the test. In the second set, rats (n=6-10) were injected with GAL 3nmol, GAL(1-15) 3nmol or vehicle 15min before the OFT. Time and entries in the central square during 300 Sec. were scored. In the FST, the increase in the immobility induced by GAL(1-15) was significantly higher (p<0.01) than the one induced by GAL. In the climbing response GAL(1-15) also induced a significantly stronger decrease (p<0.05) in climbing compared with GAL. In the OFT, GAL(1-15) significantly decrease the number of entries (p<0.01) and time (p<0.05) in centre while GAL lacks of effect. These results indicate that GAL(1-15) has more powerful effects than GAL in depression-like behaviour in the FST and anxiogenic-like effects in the OFT. These findings may give the basis for the development of novel therapeutic drugs targeting GAL(1-15) system for treatment of depression and anxiety disorders.es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDepresión mentales_ES
dc.subjectNeurorreceptoreses_ES
dc.subject.otherGalanines_ES
dc.subject.otherGalanin fragment 1-15es_ES
dc.subject.otherDepressiones_ES
dc.subject.otherAnxietyes_ES
dc.titleGalanin N-Terminal fragment (1-15) induces a stronger effect than Galanin in depression- and anxiety- like related behavioural tests in rats.es_ES
dc.typeinfo:eu-repo/semantics/otheres_ES
dc.centroFacultad de Medicinaes_ES
dc.relation.eventtitle9th FENS Forum of Neurosciencees_ES
dc.relation.eventplaceMilán, Italiaes_ES
dc.relation.eventdate5-9 Julio 2014es_ES


Ficheros en el ítem

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem