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Galanin N-Terminal fragment (1-15) induces a stronger effect than Galanin in depression- and anxiety- like related behavioural tests in rats.
dc.contributor.author | Millón-Peñuela, Carmelo | |
dc.contributor.author | Narváez-Peláez, Manuel | |
dc.contributor.author | Flores-Burgess, Antonio | |
dc.contributor.author | Parrado-Romero, Concepción | |
dc.contributor.author | Puigcerver-Martínez, Araceli | |
dc.contributor.author | Coveñas, Rafael | |
dc.contributor.author | Santín-Núñez, Luis Javier | |
dc.contributor.author | Borroto Escuela, Dasiel Óscar | |
dc.contributor.author | Fuxe, Kjell | |
dc.contributor.author | Narváez-Bueno, José Ángel | |
dc.contributor.author | Díaz-Cabiale, Zaida | |
dc.date.accessioned | 2014-07-16T11:03:35Z | |
dc.date.available | 2014-07-16T11:03:35Z | |
dc.date.created | 2014-07 | |
dc.date.issued | 2014-07-16 | |
dc.identifier.uri | http://hdl.handle.net/10630/7853 | |
dc.description.abstract | Galanin (GAL) and GAL Receptors are implicated in anxiety- and depression- related behaviours. The GAL N-terminal fragment (1-15) [GAL(1-15)] also induces depressant- and anxiogenic- like actions. In this work, we have compared the effects of GAL and GAL(1-15) in depression- and anxiety- related behaviours using the Forced Swimming Test (FST) and the Open Field Test (OFT). In the first set of experiments, rats (n=8-10) were injected with GAL 3nmol, GAL(1-15) 3nmol or vehicle 15min before the FST. Two sessions were conducted: a 15min. pre-test followed 24h later by 5min. test. The duration of immobility and climbing were recorded during the test. In the second set, rats (n=6-10) were injected with GAL 3nmol, GAL(1-15) 3nmol or vehicle 15min before the OFT. Time and entries in the central square during 300 Sec. were scored. In the FST, the increase in the immobility induced by GAL(1-15) was significantly higher (p<0.01) than the one induced by GAL. In the climbing response GAL(1-15) also induced a significantly stronger decrease (p<0.05) in climbing compared with GAL. In the OFT, GAL(1-15) significantly decrease the number of entries (p<0.01) and time (p<0.05) in centre while GAL lacks of effect. These results indicate that GAL(1-15) has more powerful effects than GAL in depression-like behaviour in the FST and anxiogenic-like effects in the OFT. These findings may give the basis for the development of novel therapeutic drugs targeting GAL(1-15) system for treatment of depression and anxiety disorders. | es_ES |
dc.description.sponsorship | Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. | es_ES |
dc.language.iso | eng | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Depresión mental | es_ES |
dc.subject | Neurorreceptores | es_ES |
dc.subject.other | Galanin | es_ES |
dc.subject.other | Galanin fragment 1-15 | es_ES |
dc.subject.other | Depression | es_ES |
dc.subject.other | Anxiety | es_ES |
dc.title | Galanin N-Terminal fragment (1-15) induces a stronger effect than Galanin in depression- and anxiety- like related behavioural tests in rats. | es_ES |
dc.type | info:eu-repo/semantics/other | es_ES |
dc.centro | Facultad de Medicina | es_ES |
dc.relation.eventtitle | 9th FENS Forum of Neuroscience | es_ES |
dc.relation.eventplace | Milán, Italia | es_ES |
dc.relation.eventdate | 5-9 Julio 2014 | es_ES |