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    •   RIUMA Principal
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    • Química Orgánica - (QO)
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    Preparation, photophysical properties and cell image of Naphthalimide-based fluorescent nanostructures for biomedical applications: BAPAD dendrimeric antigens and silica nanoparticles

    • Autor
      Mesa, Pablo; Collado, DanielAutoridad Universidad de Málaga; Vida-Pol, YolandaAutoridad Universidad de Málaga; Najera-Albendin, FranciscoAutoridad Universidad de Málaga; Perez-Inestrosa, Ezequiel
    • Fecha
      2014-07-17
    • Palabras clave
      Fotoquímica
    • Resumen
      We present here the synthesis and characterization of BAPAD [1] fluorescent Dendrimeric-Antigens (DeAn), to be applied in basophil activation as a test to detect drug allergy reactions. A second generation BAPAD dendrimer using cystamine as core that can be reducced to obtain two dendrons with a thiol group in the focal point, useful to attach a fluorescent probe, have been synthesized. The free amine groups on the surface of the dendrimer were functionalized with an amoxiciloyl group (AXO), the allergenic determinant to the beta-lactam antibiotic amoxicillin. The fluorescent DeAn (F-DeAn) has been fully characterized by NMR and MS techniques, and their fluorescent properties well established in aqueous biological media. F-DeAn without the haptenic moieties at the periphery has been also obtained and fully characterized as a control assay. Both molecules have been also characterized using molecular dynamics simulation calculations. We show here how these dendrimeric structures interacts with dendritic cells and are internalized by them. In a secon approximation, Naphthalimide-fluorscent silica nanoparticles have been prepared and characterized, to be used also in basophil activation test.
    • URI
      http://hdl.handle.net/10630/7857
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    abstract_template_4jif_EPerezInestrosa.pdf (14.20Kb)
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    REPOSITORIO INSTITUCIONAL UNIVERSIDAD DE MÁLAGA
    REPOSITORIO INSTITUCIONAL UNIVERSIDAD DE MÁLAGA