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dc.contributor.authorFlores-Burgess, Antonio
dc.contributor.authorDíaz-Cabiale, Zaida 
dc.contributor.authorMillón Peñuela, Carmelo
dc.contributor.authorNarváez, Manuel 
dc.contributor.authorNarváez, José Ángel 
dc.date.accessioned2014-09-30T08:49:16Z
dc.date.available2014-09-30T08:49:16Z
dc.date.created2014-09-29
dc.date.issued2014-09-30
dc.identifier.urihttp://hdl.handle.net/10630/8136
dc.description.abstractGalanin (GAL) and N-terminal Galanin fragment (1-15) [GAL(1-15)] interact at membrane level with Neuropeptide Y receptors. In the nucleus of the solitary tract GAL modified the cardiovascular action of the NPYY1 and GAL(1-15) facilitated the NPYY2 agonist effect. Recently, we observed that in the amygdala, GAL increased the anxiolytic effect and the binding of the NPYY1 agonist. The aim of this work was to study if GAL(1-15) interacts as well with NPYY1 receptors in the amygdala. We analyzed the binding of the NPYY1 agonist [125I]-Leu31-Pro34-PPY (25pM) in the presence of GAL(1-15) at different doses. The GAL antagonist M40 was also used. In behavioural experiments, groups of rats (n=8-10) received intracerebroventricular GAL(1- 15)(1nM) and Leu31-Pro34-NPY (0.1nM or 3nM) alone or in combination fifteen minutes before starting 5-minute session in the open field (OF) and in the elevated plus maze (EPM). We analyzed the number of entries and time in the central square of OF and the percentages of entries and time in the open arms of EPM. GAL(1-15) at 1nM increased the NPYY1 agonist binding by 10% (p<00.1) in amygdala, M40 blocked this effect. In the behavioral tests, GAL(1-15) did not change the effect of NPYY1 in the OF or EPM. These results indicate that in the amygdala, GAL(1-15) interacts with NPYY1 receptor at membrane level but not in the unconditioned anxiety-like tests. These results may be of relevance for GAL(1-15) mediated actions in the central nervous system.es_ES
dc.description.sponsorshipThis work has been supported by the Junta de Andalucia CVI6476.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectNeuropéptidoses_ES
dc.subject.otherGalanin (1-15)es_ES
dc.subject.otherNPYY1 Res_ES
dc.subject.otheramygdalaes_ES
dc.titleGalanin (1-15) increased the neuropétide-Y Y1 receptor bindng in the amygdala of the ratses_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Medicinaes_ES
dc.relation.eventtitleXXXVII CONGRESS OF THE SPANISH SOCIETY OF PHYSIOLOGICAL SCIENCES (SECF)es_ES
dc.relation.eventplaceGranada, españaes_ES
dc.relation.eventdate24/09/2014es_ES


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