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dc.contributor.authorVan der Selt, Marcelis
dc.date.accessioned2015-04-15T09:58:39Z
dc.date.available2015-04-15T09:58:39Z
dc.date.issued2015-04-15
dc.identifier.urihttp://hdl.handle.net/10630/9658
dc.description.abstractEndocannabinoids play an essential role in human health and disease, regulating processes such as immunomodulation, energy balance and neurotransmission. Diacylglycerollipase-α (DAGL-α) is responsible for the production of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the central nervous system. It is a potential drug target for the treatment of obesity and neurodegenerative diseases. Currently, there are no selective inhibitors and activity-based probes available for its study. The identification of selective DAGL- inhibitors is hampered by a lack of assays that make use of endogenous DAGL- activity in proteomes. Determination of the selectivity of the inhibitors in native tissues is important, because DAGL- belongs to the class of serine hydrolases, containing more than 200 members with various physiological functions. Here, I will present a chemical biology approach to identify and characterize highly selective chemical probes to study the function of this protein both in vitro and in vivo.es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectReceptores de neurotransmisoreses_ES
dc.subject.otherEndocannabinoids DAGL-alfa inhibitorses_ES
dc.titleA chemical biology approach to control endocannabinoid biosynthesises_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Psicologíaes_ES
dc.relation.eventtitleDpt. Psicobiología y Metodología de las Ciencias del Comportamientoes_ES
dc.relation.eventplaceMálaga, Españaes_ES
dc.relation.eventdate26/06/2015es_ES


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