Diagnosis of immediate reactions to amoxicillin: Comparison of basophil activation markers CD63 and CD203c in a prospective study

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Allergy - 2022 - C spedes - Diagnosis of immediate reactions to amoxicillin Comparison of basophil activation markers CD63.pdf (7.05 MB)

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URI: https://hdl.handle.net/10630/26461
DOI: DOI: 10.1111/all.15610

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2022-12-07

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Wiley

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Biología Celular, Genética y Fisiología

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Agentes anticancerosos
Amoxicilina
Basófilos
Diágnosticos

Abstract

Amoxicillin (AX) combined or not with clavulanic acid (CLV) is frequently involved in IgE-mediated reactions. Drug provocation test (DPT) is considered as the gold standard for diagnosis, although contraindicated in high-risk patients. Basophil activation test (BAT) can help diagnose immediate reactions to beta-lactams, although controversy exists regarding the best activation marker. We have performed a real-life study in a prospective cohort to analyze the real value of BAT as diagnostic tool and the best activation marker, CD63 and CD203c, for the evaluation of immediate reactions to these drugs.

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Céspedes, J. A., Fernández‐Santamaría, R., Ariza, A., Bogas, G., Doña, I., Rondón, C., ... & Fernández, T. D. (2022). Diagnosis of immediate reactions to amoxicillin: Comparison of basophil activation markers CD63 and CD203c in a prospective study. Allergy.

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwised noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional