Diagnosis of immediate reactions to amoxicillin: Comparison of basophil activation markers CD63 and CD203c in a prospective study

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dc.centroFacultad de Cienciases_ES
dc.contributor.authorCéspedes Lagos, José Antonio
dc.contributor.authorFernández-Santamaría, Rubén
dc.contributor.authorAriza Veguillas, Adriana
dc.contributor.authorBogas Herrera, Gádor
dc.contributor.authorDoña, Inmaculada
dc.contributor.authorRondón, Carmen
dc.contributor.authorSalas, María
dc.contributor.authorLabella, Marina
dc.contributor.authorFrecha, Cecilia
dc.contributor.authorMayorga Mayorga, Cristobalina
dc.contributor.authorTorres-Jaén, María Josefa
dc.contributor.authorFernández-Duarte, Tahía Diana
dc.date.accessioned2023-05-04T11:12:56Z
dc.date.available2023-05-04T11:12:56Z
dc.date.created2023-05-03
dc.date.issued2022-12-07
dc.departamentoBiología Celular, Genética y Fisiología
dc.description.abstractAmoxicillin (AX) combined or not with clavulanic acid (CLV) is frequently involved in IgE-mediated reactions. Drug provocation test (DPT) is considered as the gold standard for diagnosis, although contraindicated in high-risk patients. Basophil activation test (BAT) can help diagnose immediate reactions to beta-lactams, although controversy exists regarding the best activation marker. We have performed a real-life study in a prospective cohort to analyze the real value of BAT as diagnostic tool and the best activation marker, CD63 and CD203c, for the evaluation of immediate reactions to these drugs.es_ES
dc.description.sponsorshipWe thank Claudia Corazza for her invaluable English language support; Verónica Prados and Ana Molina for their help in technical support in flow cytometry methods. This work has been supported by Institute of Health “Carlos III” (ISCIII) of the Ministry of Economy and Competitiveness (MINECO; grants co-funded by European Regional Development Fund: PI15/01206, PI17/01237, PI18/00095, PI20/01734, RETICS ARADYAL RD16/0006/0001, and RICORS REI (RD21/0002/0008); Andalusian Regional Ministry of Health (grants PI-0241-2016, PE-0172-2018, and PI-0127-2020); Spanish Ministerio de Ciencia e Innovación Proyectos de I + D + I «Programación Conjunta Internacional», EuroNanoMed 2019 (PCI2019-111825-2)). AA holds a Senior Postdoctoral Contract (RH-0099-2020) with the Andalusian Regional Ministry of Health (cofunded by European Social Fund (ESF): "Andalucía se mueve con Europa". GB holds a “Juan Rodes” contract (JR18/00054) by ISCIII of MINECO (cofounded by ESF). ID holds a clinical research stabilization contract by Andalusian Regional Ministry of Health (RB-0001-2022). ML holds a “Rio Hortega” contract (CM20/00210) by ISCIII of MINECO (cofounded by ESF). CF holds a Marie Skłodowska-Curie Individual Fellowship by the European Union's Horizon 2020 research and innovation program (agreement n° PI-0241-2016101027955). CM holds a “Nicolas Monardes” research contract by Andalusian Regional Ministry of Health (RC-0004-2021). // Funding for open access charge: Universidad de Málaga / CBUA.es_ES
dc.identifier.citationCéspedes, J. A., Fernández‐Santamaría, R., Ariza, A., Bogas, G., Doña, I., Rondón, C., ... & Fernández, T. D. (2022). Diagnosis of immediate reactions to amoxicillin: Comparison of basophil activation markers CD63 and CD203c in a prospective study. Allergy.es_ES
dc.identifier.doiDOI: 10.1111/all.15610
dc.identifier.urihttps://hdl.handle.net/10630/26461
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.accessRightsopen accesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAgentes anticancerososes_ES
dc.subjectAmoxicilinaes_ES
dc.subjectBasófiloses_ES
dc.subjectDiágnosticoses_ES
dc.subject.otherAmoxicilinaes_ES
dc.subject.otherCD63es_ES
dc.subject.otherCD203ces_ES
dc.titleDiagnosis of immediate reactions to amoxicillin: Comparison of basophil activation markers CD63 and CD203c in a prospective studyes_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
relation.isAuthorOfPublicationabcd4607-b47d-4018-86ad-3b5f76cbee1e
relation.isAuthorOfPublicationec13929c-d0d4-4616-ac5f-411b50d3e75a
relation.isAuthorOfPublication.latestForDiscoveryabcd4607-b47d-4018-86ad-3b5f76cbee1e

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