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dc.contributor.authorRomero-Sánchez, Lilian B.
dc.contributor.authorMari-Beffa, Manuel 
dc.contributor.authorCarrillo Fernández, Paloma
dc.contributor.authorMedina Torres, Miguel Ángel
dc.contributor.authorDíaz-Cuenca, Aránzazu
dc.date.accessioned2018-10-19T09:46:17Z
dc.date.available2018-10-19T09:46:17Z
dc.date.created2018
dc.date.issued2018-10-19
dc.identifier.urihttps://hdl.handle.net/10630/16663
dc.description.abstractThe osteogenic and angiogenic responses of organisms to the ionic products of degradation of bioactive glasses (BGs) are being intensively investigated. The promotion of angiogenesis by copper (Cu) has been known for more than three decades. This element can be incorporated to delivery carriers, such as BGs, and the materials used in biological assays. In this work, Cu-containing mesoporous bioactive glass (MBG) in the SiO2-CaO-P2O5 compositional system was prepared incorporating 5% mol Cu (MBG-5Cu) by replacement of the corresponding amount of Ca. The biological effects of the ionic products of MBG biodegradation were evaluated on a well-known endothelial cell line, the bovine aorta endothelial cells (BAEC), as well as in an in vivo zebrafish (Danio rerio) embryo assay. The results suggest that ionic products of both MBG (Cu free) and MBG-5Cu materials promote angiogenesis. In vitro cell cultures show that the ionic dissolution products of these materials are not toxic and promote BAEC viability and migration. In addition, the in vivo assay indicates that both exposition and microinjection of zebrafish embryos with Cu free MBG material increase vessel number and thickness of the subintestinal venous plexus (SIVP), whereas assays using MBG-5Cu enhance this effect.en_US
dc.description.sponsorshipThe authors gratefully acknowledge the financial support provided by the Andalusian Ministry of Economy, Science and Innovation (Proyectos Excelencia Grants no. P10-CTS-6681 and no. P12-CTS-1507) and Spanish Ministry of Economy and Competitivity (BIO2014-56092-R). LBRS acknowledges the CONACYT-Mexico Fellowship PhD Program.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectNeovascularizaciónen_US
dc.subject.otherBioactive glassen_US
dc.subject.otherZebrafishen_US
dc.subject.otherAngiogenesisen_US
dc.titleCopper-containing mesoporous bioactive glass promotes angiogenesis in an in vivo zebrafish modelen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.centroFacultad de Cienciasen_US
dc.identifier.doi10.1016/j.actbio.2017.12.032
dc.rights.ccAttribution-NonCommercial-NoDerivatives 4.0 Internacional*


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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