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dc.contributor.authorMoreno-Fernández, Román
dc.contributor.authorBacq, Alexandre
dc.contributor.authorRosell-Valle, Crisitina
dc.contributor.authorZanoletti, Olivia
dc.contributor.authorCifuentes, Manuel 
dc.contributor.authorPérez-Martín, Margarita 
dc.contributor.authorGarcía-Fernández, María I.
dc.contributor.authorEstivill-Torrús, Guillermo
dc.contributor.authorRodríguez de Fonseca, Fernándo
dc.contributor.authorSantin-Nuñez, Luis Javier 
dc.contributor.authorSandi, Carmen
dc.contributor.authorPedraza-Benítez, Maria del Carmen 
dc.date.accessioned2019-06-25T06:43:12Z
dc.date.available2019-06-25T06:43:12Z
dc.date.created2019-06
dc.date.issued2019-06-25
dc.identifier.urihttps://hdl.handle.net/10630/17873
dc.description.abstractThe LPA1, one of the six characterized G protein-coupled receptors (LPA1–6) through which lysophosphatidic acid acts may be involved in promoting normal emotional behaviors. Evidence also imply a role for the LPA1 receptor in mediating the consequences of stress on the hippocampus. However, to date, there is not available information regarding the mechanisms whereby the LPA1 receptor mediates this adaptation. Changes in glutamate/GABA cycling could be one possible mechanism. To gain further insight into how LPA-LPA1 may prevent the negative consequences of chronic stress, we assessed the effects of chronic ICV administration of LPA on depressive-like behaviours induced by a chronic restraint stress protocol. Then, gene expression for molecular markers for excitatory and inhibitory neurotransmission was determined. In addition, the hippocampal expression of mineralocorticoid receptor and glucocorticoid receptor genes and proteins were determined, as well as plasma corticosterone levels. Contrary to expectations, the continuous delivery of LPA in chronically stressed animals instead of inhibiting, potentiated some, though not all, negative effects of stress. Furthermore, this treatment induced as well altered the excitatory/inhibitory balance in the ventral hippocampus. In conclusion, the results of this study reinforce the assumption that LPA, mainly through the LPA1 receptor, regulates hippocampal-dependent behaviour and functions.en_US
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. Funding: This study was supported by Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía (SEJ1863 to C.P.; CTS-643 to G.E.-T), Ministerio de Economía y Competitividad and the European Regional Development Fund (PSI2017-83408-P to C.P.), Consejería de Salud de la Junta de Andalucía (NICOLÁS MONARDE Program to G.E:T) Ministerio de Educación, Cultura y Deporte (FPU14/01610 to R.D.M.-F.; FPDI2010 to C.R-V. (Junta de Andalucía) and intramural funding from the EPFL to C.S. I Plan propio de investigación y transferencia de la Universidad de Málaga (Congress attendance of C.P).en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEstrés emocionalen_US
dc.subjectHipocampo (Cerebro) - Congresosen_US
dc.subject.otherlysophosphatidic acid, LPA, chronic stress, animal models of depression, hippocampusen_US
dc.titleStress, depression and the hippocampus: modulatory effects of continuous LPA treatmenten_US
dc.typeinfo:eu-repo/semantics/otheren_US
dc.centroFacultad de Psicologíaen_US
dc.relation.eventtitleIII international Congress of Psychobiologyen_US
dc.relation.eventplaceGranadaen_US
dc.relation.eventdateMayo 2019en_US


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