[Purpose] Non-invasive and drug-free interventions for pain are being developed. One of them is ANF
(which stands for “Amino Neuro Frequency”) Therapy®, which consists in the application of carbonized metal devices
on a patient’s skin. We aimed to: 1) test perceived changes in pain intensity after ANF application, 2) record
frequency and severity of side effects, 3) assess clinician and patient satisfaction, 4) explore effects on swelling and
range of motion (ROM). [Participants and Methods] In this real-world multisite observational study, N=113 physical
therapists in 45 countries, applied ANF to N=1,054 patients (Mage=45.2, 56.2% female) with pain complaints.
Demographic data, pain intensity (NRS-11), effects of ANF on swelling and ROM, clinician and patient satisfaction
and side effects were collected. [Results] Main pain locations were: low back (14.9%), knee (12.4%), neck (10%),
and shoulder (9.6%). Pre-treatment pain intensity was high (Mean=7.6, SD=1.9). It significantly decreased posttreatment
(Mean=3.1, SD=2.0), t(1053)=7.25, with a large effect size (Cohen’s d=2.2). Swelling decreased and ROM
increased. Average satisfaction with ANF was 92/100. Patients often experienced mild side effects (42.3%): dry
mouth, headache and fatigue. [Conclusion] Results show large effect sizes, high satisfaction, and mild and shortterm
side effects. This is very promising but should be interpreted with caution considering the study limitations.
