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dc.contributor.authorXian, Liu
dc.contributor.authorYu, Gang
dc.contributor.authorWei, Yali
dc.contributor.authorRufián Plaza, José Sebastián
dc.contributor.authorLi, Yansha
dc.contributor.authorZhuang, Haiyan
dc.contributor.authorXue, Hao
dc.contributor.authorMorcillo, Rafael J
dc.contributor.authorMacho, Alberto P
dc.date.accessioned2024-09-02T08:50:39Z
dc.date.available2024-09-02T08:50:39Z
dc.date.issued2020
dc.identifier.citationXian L, Yu G, Wei Y, Rufian JS, Li Y, Zhuang H, Xue H, Morcillo RJL, Macho AP. A Bacterial Effector Protein Hijacks Plant Metabolism to Support Pathogen Nutrition. Cell Host Microbe. 2020 Oct 7;28(4):548-557.e7. doi: 10.1016/j.chom.2020.07.003. Epub 2020 Jul 30.es_ES
dc.identifier.urihttps://hdl.handle.net/10630/32489
dc.descriptionPolítica de acceso abierto tomada de: https://v2.sherpa.ac.uk/id/publication/6581es_ES
dc.description.abstractMany bacterial plant pathogens employ a type III secretion system to inject effector proteins within plant cells to suppress plant immunity. Whether and how effector proteins also co-opt plant metabolism to support extensive bacterial replication remains an open question. Here, we show that Ralstonia solanacearum, the causal agent of bacterial wilt disease, secretes the effector protein RipI, which interacts with plant glutamate decarboxylases (GADs) to alter plant metabolism and support bacterial growth. GADs are activated by calmodulin and catalyze the biosynthesis of gamma-aminobutyric acid (GABA), an important signaling molecule in plants and animals. RipI promotes the interaction of GADs with calmodulin, enhancing the production of GABA. R. solanacearum is able to replicate efficiently using GABA as a nutrient, and both RipI and plant GABA contribute to a successful infection. This work reveals a pathogenic strategy to hijack plant metabolism for the biosynthesis of nutrients that support microbial growth during plant colonization.es_ES
dc.language.isoenges_ES
dc.publisherCell Presses_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectPlantas - Metabolismoes_ES
dc.subjectBacterias fitopatógenases_ES
dc.subject.otherRipIes_ES
dc.subject.otherRalstonia solanacearumes_ES
dc.subject.otherGABAes_ES
dc.subject.otherEffectorses_ES
dc.titleA Bacterial Effector Protein Hijacks Plant Metabolism to Support Pathogen Nutrition.es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.1016/j.chom.2020.07.003
dc.rights.ccAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersiones_ES


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