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Galanin n-terminal fragment (1-15) decreases the voluntary alcohol intake in rats
dc.contributor.author | Millón-Peñuela, Carmelo | |
dc.contributor.author | Flores-Burgess, Antonio | |
dc.contributor.author | Castilla-Ortega, María Estela | |
dc.contributor.author | Gago-Calderón, Belén | |
dc.contributor.author | Serrano, Antonia | |
dc.contributor.author | Sturla, Antonella | |
dc.contributor.author | García-Durán, Laura | |
dc.contributor.author | Narváez-Bueno, José Ángel | |
dc.contributor.author | Fuxe, Kjell | |
dc.contributor.author | Santín-Núñez, Luis Javier | |
dc.contributor.author | Díaz-Cabiale, Zaida | |
dc.date.accessioned | 2018-06-28T06:44:52Z | |
dc.date.available | 2018-06-28T06:44:52Z | |
dc.date.created | 2018 | |
dc.date.issued | 2018-06-28 | |
dc.identifier.uri | https://hdl.handle.net/10630/16037 | |
dc.description.abstract | Galanin (GAL) is involved in drug abuse and addiction including alcohol intake. In this work, we have analysed the role of the N-terminal GAL fragment (1-15) [GAL(1-15)] in voluntary ethanol consumption in rats using the two-bottle choice paradigm as well as compare the effects of GAL(1-15) with GAL. The two-bottle choice test was used to determine the voluntary ethanol consumption of rats (Castilla-Ortega et al., 2016). Three sets of experiments were conducted. In the first set of experiments, a dose-response curve of GAL(1-15) was performed. Groups of rats (n=7-9) received i.c.v. GAL(1-15) 1 nmol, 3 nmol or vehicle 2, 14 and 24 hours before the measures. In the second set of experiments, the effects in two-bottle choice test of GAL 3 nmol, and GAL(1-15) 3 nmol were compared. In the last set of experiments rats received i.c.v. GAL(1-15) 3nmol combined with GALR2 antagonist M871 3 nmol 2 hours before the measures. GAL(1-15) 3nmol significantly decreased the alcohol intake 2 (p<0.05), 14 (p<0.05) and 24 (p<0.05) hours after its administration. Moreover, 2 hours after i.c.v. GAL(1-15) 3nmol a significantly decreased by 90% in preference was observed (p<0.05). This effect was maintained 24hours. GAL(1-15) also significantly reduced the alcohol intake (p<0.05) and preference (p<0.05) compared with GAL. GALR2 antagonist M871 significantly blocked the decreased in the ethanol intake (p<0.05) and preference (p<0.05) induced by GAL(1-15) 2 hours after its administration. These results indicates that GAL(1-15) induces a strong reduction in preference and alcohol consumption in rat, showing a differential role than GAL. These results may give basis for the development of novel therapeutic strategies using GAL(1-15) for treatment of alcohol addiction. | en_US |
dc.description.sponsorship | Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. This study was supported by Spanish SAF2016-79008-P and PPIT.UMA.B1.2017/17. | en_US |
dc.language.iso | eng | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Péptidos | en_US |
dc.subject | Alcoholismo | en_US |
dc.subject.other | Galanin | en_US |
dc.subject.other | Galanin (1-15) | en_US |
dc.subject.other | Alcoholism | en_US |
dc.subject.other | Addiction | en_US |
dc.title | Galanin n-terminal fragment (1-15) decreases the voluntary alcohol intake in rats | en_US |
dc.type | info:eu-repo/semantics/conferenceObject | en_US |
dc.centro | Facultad de Medicina | en_US |
dc.relation.eventtitle | CINP 31st World Congress | en_US |
dc.relation.eventplace | Viena, Austria | en_US |
dc.relation.eventdate | 16/06/2018 al 19/06/2018 | en_US |