• AD0157, a pyrrolidinedione fungal metabolite, inhibits angiogenesis by targeting the Akt signaling pathway 

      García-Caballero, Melissa; Cañedo, Librada; Fernández-Medarde, Antonio; Quesada, Ana R.; Medina Torres, Miguel Ángel (2014-09-16)
      In the course of a screening program for the inhibitors of angiogenesis from marine sources, AD0157, a pyrrolidinedione fungal metabolite, was selected for its angiosupressive properties. AD0157 inhibited the growth of ...
    • El análogo de las estrigolactonas GR-24 inhibe la angiogénesis in vitro e in vivo 

      Carrillo, Paloma; Martínez-Poveda, Beatriz; Medina, Miguel Ángel; Quesada, Ana R. (2016-10-03)
      Muchas fitohormonas han mostrado un gran potencial en la prevención y terapia contra el cáncer. Las estrigolactonas son hormonas vegetales derivadas de los caroteinoides que están implicadas en la inhibición de la ramificación ...
    • Antitumor and antiangiogenic potential of solomonamide synthesis intermediates 

      Carrilo, Paloma; Cheng-Sánchez, Iván; Ocaña, Mª Carmen; Martínez-Poveda, Beatriz; Medina, Miguel Ángel; [et al.] (2017-11-09)
      In this work we developed a new synthetic strategy towards the solomonamides. a novel class of cyclopeptides of marine origin. The described synthetic approach utilized an olefin metathesis reaction to form the [15]-membered ...
    • Estudios de preferencia metabólica en células del “microambiente angiogénico” 

      Ocaña, Mª Carmen; Martínez-Poveda, Beatriz; Quesada, Ana R.; Medina, Miguel Ángel (2016-10-03)
      El "redescubrimiento" del efecto Warburg a principios de este siglo XXI y de la elevada glutaminolisis tumoral han contribuido a un renovado interés por el metabolismo en Oncología. Además, estudios recientes han dado ...
    • Fasentin, a glucose uptake inhibitor, is also able to inhibit angiogenesis 

      Ocaña, Mª Carmen; Carrillo, Paloma; Martínez-Poveda, Beatriz; Quesada, Ana R.; Medina, Miguel Ángel (2017-10-31)
      The role of glucose on endothelial cell (EC) metabolism and angiogenesis has been an emerging issue in the last few years. Some inhibitors of glucose metabolism, such as 2-deoxyglucose, have been shown to have anti-angiogenic ...
    • Homocysteine treatment alters redox capacity of both endothelial and tumor cells 

      Díaz-Santiago, Elena; Rodríguez Caso, Luis; Cárdenas, Casimiro; Serrano, José J.; Quesada, Ana R.; [et al.] (2015-10-22)
      Homocysteine is a non-proteinogenic amino acid playing key roles in two interconnected metabolic pathways, namely, the activated methyl cycle and the linear trans-sulfuration pathway that allows the conversion of methionine ...
    • Identification and characterization of new anti-angiogenic compounds from natural sources 

      Carrillo, Paloma; Ocaña, Mª Carmen; Martínez-Poveda, Beatriz; Medina, Miguel Ángel; Quesada, Ana R. (2017-07-21)
      The inhibition of angiogenesis has attracted broad attention in the field of pharmacological research, not only for cancer, but for other angiogenesis dependent diseases including ophthalmic, cutaneous and inflammatory ...
    • Interplay between glucose and palmitate uptake in breast carcinoma in vitro 

      Ocaña, Mª Carmen; Carrillo, Paloma; Martínez-Poveda, Beatriz; Quesada, Ana R.; Medina, Miguel Ángel (2018-07-17)
      One of the most studied tumor cells lines in vitro is the breast carcinoma MDA-MB-231 cell line. Several studies have proved its glycolytic profile, namely known as the Warburg effect. Glutamine oxidation is also important ...
    • Lactate Oxidation in Endothelial Cells: A Feature of All Endothelial Cells? 

      Ocaña-Ocaña, Maria del Carmen; Martínez-Poveda, Beatriz; Quesada, Ana R.; Medina, Miguel Ángel (2019-04-24)
      Metabolism of endothelial cells is a topic that has gained an increasing interest in the last years. This is due to their role in the angiogenic process, which is pathologically upregulated in several diseases, such as ...
    • Metabolic preference studies in cells of the tumor microenvironment 

      Ocaña, Mª Carmen; Martínez-Poveda, Beatriz; Quesada, Ana R.; Medina, Miguel Ángel (2016-10-03)
      In the last years, the rediscovery of the Warburg effect and high tumoral glutaminolysis has lead to a renewed interest in cancer metabolism. Moreover, recent studies have put some importance in endothelial cells metabolism. ...
    • Role of glucose, glutamine and palmitate in endothelial and tumor metabolism 

      Ocaña, Mª Carmen; Martínez-Poveda, Beatriz; Quesada, Ana R.; Medina, Miguel Ángel (2016-12-22)
      Glucose and glutamine are the major sources of energy for mammalian cells. In tumors, Warburg effect and glutaminolysis have been largely studied. On the other hand, a major role of glucose in angiogenesis has been ...